解放军医学院学报2025，Vol.46Issue(5)：435-441,7.DOI:10.12435/j.issn.2095-5227.2025.S24092305
基于孟德尔随机化的静脉炎与多发性骨髓瘤因果关联双向分析及血管生成素-1受体的中介效应研究
Two-way analysis of causal association between phlebitis and multiple myeloma and mediating effect of angiopoietin-1 receptor based on Mendelian randomization
摘要
Abstract
Background Multiple myeloma is a malignancy that affects the blood,and phlebitis involves inflammation and thrombosis of blood vessels.In clinical cases,patients with multiple myeloma are often accompanied by phlebitis.There may be some potential relationship between the two,but the specific mechanism is not clear.Objective To evaluate the relationship between phlebitis and multiple myeloma,and investigate whether the level of angiopoietin-1 receptor plays a mediating role in this relationship.Methods Two-way two-sample Mendelian randomization(MR)was used to analyze the GWAS data of phlebitis and multiple myeloma in IEU Open GWAS database,the relationship between phlebitis and multiple myeloma were investigated,and the mediating role of angiopoietin-1 receptor level between phlebitis and multiple myeloma was explored by two-step MR analysis.Inverse variance weighting(IVW)was used as the main MR analysis method,MR-Egger regression was used to test horizontal pleiotropy,and sensitivity analysis was performed by leave-one-out test.The MR results were visualized by scatter plot,forest plot and funnel plot.Results There was no independent causal relationship between phlebitis and the occurrence of multiple myeloma(OR=0.999,95%CI:0.997-1.003,P=0.638).The risk of multiple myeloma increased when phlebitis occurred(OR=1.005,95%CI:1.001-1.009,P=0.009).The level of angiopoietin-1 receptor increased the risk of phlebitis(OR=1.053,95%CI:1.017-1.092,P=0.004).The risk of multiple myeloma increased with the increase of angiopoietin-1 receptor level(OR=1.006,95%CI:1.002-1.010,P=0.004).Conclusion Phlebitis may increase the risk of multiple myeloma and angiopoietin-1 receptor levels may be a potential mediator between phlebitis and multiple myeloma.关键词
孟德尔随机化/静脉炎/多发性骨髓瘤/血管生成素-1受体水平/中介效应Key words
Mendelian randomization/phlebitis and thrombophlebitis/multiple myeloma/angiopoietin-1 receptor levels/mediating effect分类
医药卫生引用本文复制引用
张辉,耿杰,侯传东,贺培凤,卢学春..基于孟德尔随机化的静脉炎与多发性骨髓瘤因果关联双向分析及血管生成素-1受体的中介效应研究[J].解放军医学院学报,2025,46(5):435-441,7.基金项目
国家重点研发计划(2021YFC2701703) （2021YFC2701703）
