南京中医药大学学报2025，Vol.41Issue(8)：1021-1026,6.DOI:10.14148/j.issn.1672-0482.2025.1021
基于络病理论探讨益气解毒化瘀法防治腹膜透析相关腹膜纤维化
Exploration of the Prevention and Treatment of Peritoneal Dialysis-Related Peritoneal Fibrosis with Invigorating Qi,Detoxif-ying,and Resolving Stasis Method Based on Collateral Disease Theory
摘要
Abstract
Peritoneal fibrosis(PF)is an important reason that restricts long-term treatment of peritoneal dialysis(PD).Based on the theory of collateral disease,PF is considered to be an abdominal collateral disease,with dampness as the main pathogenic factor,and collateral qi deficiency and stagnation,toxicity and blood stasis as the core pathogenesis.The peritoneum is chronically exposed to an inflammatory microenvironment induced by non-biocompatible peritoneal dialysis fluid,reflecting the pathogenic mechanism of dampness-induced pathology.The resultant pathological processes,including damage of peritoneal mesothelial cells,accumulation of inflammatory mediators and metabolic products,and angiogenesis—elucidate the scientific connotation of dampness impairing collaterals and inducing deficiency,toxicity,and stasis.On this basis,the treatment principles of invigorating qi,detoxifying,resolving stasis and unblocking collaterals were proposed,and the Qixue Huazheng prescription was formed with Astragalus as the main ingredient and Centella asiatica and Ligusticum wallichii as the compatibility,which provides a reference for the prevention and treatment of PD-relat-ed PF by traditional Chinese medicine.关键词
腹膜透析/腹膜纤维化/络病/中医病机/益气解毒化瘀Key words
peritoneal dialysis/peritoneal fibrosis/collateral disease/TCM pathogenesis/invigorating qi,detoxifying and resol-ving stasis分类
医药卫生引用本文复制引用
尤永卿,俞曼殊,单云,许嵘,严谨,孙谨怡,盛梅笑..基于络病理论探讨益气解毒化瘀法防治腹膜透析相关腹膜纤维化[J].南京中医药大学学报,2025,41(8):1021-1026,6.基金项目
国家自然科学基金面上项目(82374374) （82374374）
国家自然科学基金青年科学基金项目(82305161) （82305161）
