上海交通大学学报（医学版）2025，Vol.45Issue(8)：1017-1026,10.DOI:10.3969/j.issn.1674-8115.2025.08.009
黏性骨与自体髂骨松质骨移植修复单侧牙槽突裂成骨效果的临床研究
Clinical study on osteogenic effect of sticky bone and autologous iliac cancellous bone graft in repairing unilateral alveolar cleft
摘要
Abstract
Objective·To explore the clinical efficacy and safety of sticky bone[deproteinized porcine bone mineral granules combined with advanced platelet-rich fibrin(A-PRF)and liquid platelet-rich fibrin(L-PRF)]in the repair of unilateral alveolar cleft.Methods·Patients diagnosed with unilateral alveolar cleft who met the inclusion and exclusion criteria were recruited from December 1,2023 to August 31,2024.The patients were randomly divided into 2 groups.The experimental group received sticky bone grafts,and the control group received autologous iliac cancellous bone grafts for alveolar cleft repair.The primary efficacy index was the bone resorption rate at 6 months post-surgery,calculated by measuring the grafted bone volume immediately after surgery and at 6 months using Simplant Pro 17.01 software based on patients'computed tomography data collected before surgery,immediately after surgery,and 6 months post-surgery.Secondary efficacy indices included bone density at 6 months after surgery,the occurrence of postoperative complications in patients,and the scores on the oral health-related quality of life scale.Prism 10 software was used for data analysis,and t-test and Pearson correlation analysis methods were adopted.Results·Seventeen patients with unilateral alveolar cleft were included in the experimental group,and 15 in the control group.The remaining bone volume in the experimental group at 6 months after surgery was more than that in the control group.The bone resorption rate in the experimental group was 33.24%±17.16%,significantly lower than 66.31%±17.98%in the control group(P<0.001).One patient in the experimental group had vestibular mucosal dehiscence accompanied by bone powder discharge 2 weeks after surgery;3 patients in the control group had vestibular mucosal dehiscence accompanied by cancellous bone discharge 1 month after surgery,with one case of grafted bone necrosis 4 months after surgery.The bone density in the experimental group at 6 months after surgery was significantly higher than that in the control group(P<0.001),and the scores on the oral health-related quality of life scale were lower.Conclusion·Compared with iliac cancellous bone,when sticky bone is used in the treatment of patients with unilateral alveolar cleft,it shows a lower bone resorption rate and higher bone density,indicating better osteogenic ability.Fewer number of complications and lower scores on the oral health-related quality of life scale suggest greater safety,thereby supporting its strong potential for clinical promotion and application.关键词
单侧牙槽突裂/黏性骨/骨吸收率/骨密度/口腔健康质量/植骨术Key words
unilateral alveolar cleft/sticky bone/bone resorption rate/bone mineral density/oral health quality/bone grafting surgery分类
医药卫生引用本文复制引用
虞祖音,刘逸云,解嘉慧,蔡鸣,沈国芳..黏性骨与自体髂骨松质骨移植修复单侧牙槽突裂成骨效果的临床研究[J].上海交通大学学报（医学版）,2025,45(8):1017-1026,10.基金项目
上海市重中之重研究中心项目(NCRCO202328) （NCRCO202328）
上海交通大学医疗机器人研究院-第九人民医院临床联合研究中心项目(IMR-NPH202003) （IMR-NPH202003）
上海市科委地方院校能力建设项目(22010502600). Project of Shanghai's Top Priority Research Center(NCRCO202328) （22010502600）
Shanghai Jiao Tong University Medical Robotics Research Institute-Ninth People's Hospital Clinical Joint Research Center Project(IMR-NPH202003) （IMR-NPH202003）
Project of the Science and Technology Commission of Shanghai Municipality(22010502600). （22010502600）
