上海交通大学学报（医学版）2025，Vol.45Issue(8)：1046-1052,7.DOI:10.3969/j.issn.1674-8115.2025.08.012
乳源外泌体在肌肉衰减综合征中的研究进展
Research progress on milk-derived exosomes in sarcopenia
摘要
Abstract
Milk-derived exosomes are nanoscale extracellular vesicles naturally present in mammalian milk and are rich in proteins,lipids,nucleic acids,and bioactive metabolites.They exhibit biological activities such as anti-inflammatory,antioxidant,and immunomodulatory effects.Owing to their unique advantages of low immunogenicity,excellent biocompatibility,stability,and natural targeting ability,milk-derived exosomes have emerged as promising natural nanocarriers,garnering significant attention in disease treatment and nutritional interventions.Sarcopenia,characterized by reduced skeletal muscle mass and diminished strength,is closely associated with aging,chronic inflammation,and oxidative stress.Recent studies have highlighted the potential role of milk-derived exosomes in combating sarcopenia.These exosomes can increase myotube diameter,enhance muscle mass and fiber cross-sectional area,and improve exercise performance metrics such as grip strength.Potential mechanisms may include promoting muscle anabolism,improving mitochondrial function through antioxidant mechanisms,and modulating the inflammatory microenvironments.However,challenges remain in their application for sarcopenia at present,such as the unclear mechanisms of key bioactive components[e.g.,microRNAs(miRNAs),L-ornithine,and milk fat globule-epidermal growth factor 8(MFG-E8)],and the targeting and stability of delivery systems need to be optimized.Future research should focus on the functional analysis of components in exosomes,optimization of delivery systems,and preclinical validation to promote their practical application in managing age-related muscle health.关键词
乳源外泌体/肌肉衰减综合征/天然纳米载体Key words
milk-derived exosome/sarcopenia/natural nanocarrier分类
医药卫生引用本文复制引用
唐文静,贾洁,杨科峰,毛绚霞,宋芳芳..乳源外泌体在肌肉衰减综合征中的研究进展[J].上海交通大学学报（医学版）,2025,45(8):1046-1052,7.基金项目
教育部人文社会科学研究项目(24YJCZH273) （24YJCZH273）
上海市教育委员会上海高校实验技术队伍建设计划 （）
上海市教育科学研究项目(C2024253) （C2024253）
上海交通大学文科青年人才培育项目(2025QN038). General Project of the Ministry of Education's Humanities and Social Science Research(24YJCZH273) （2025QN038）
Shanghai University Experimental Technology Team Construction Plan by Shanghai Municipal Education Commission （）
Shanghai Educational Science Research Project(C2024253) （C2024253）
Shanghai Jiao Tong University Liberal Arts Young Talents Cultivation Program(2025QN038). （2025QN038）
