青岛大学学报（自然科学版）2025，Vol.38Issue(3)：23-27,5.DOI:10.3969/j.issn.1006-1037.2025.03.04
Drg2对IRI介导的心肌细胞焦亡的影响
Effect of Drg2 on IRI-mediated Cardiomyocyte Pyroptosis
摘要
Abstract
The regulatory role of GTP-binding protein 2(Drg2)on I/R-induced cardiomyo-cyte death was investigated using a primary cardiomyocyte hypoxia/reoxygenation IRI model constructed in suckling mice.In this model,myocardium-specific Drg2 was knocked down and overexpressed to explore the regulatory mechanism of Drg2 in cardio-myocyte death.The results show that knockdown of Drg2 inhibits IRI-mediated cardiomyocyte death,while overexpression of Drg2 promotes the elevation of the expression levels of inflamma-tory factors IL-1β,IL-18,and lactate dehydrogenase.Drg2 may play a protective role against myocardial IRI by regulating key factors of the cardiomyocyte death pathway.关键词
缺血再灌注损伤/心肌细胞/细胞焦亡Key words
ischemia-reperfusion injury/cardiomyocytes/pyroptosis分类
医药卫生引用本文复制引用
任加豪,陈鑫哲,王涛,王瑞荃,王昆..Drg2对IRI介导的心肌细胞焦亡的影响[J].青岛大学学报（自然科学版）,2025,38(3):23-27,5.基金项目
国家自然科学基金(批准号:82370291 （）
82070313)资助. （）
