摘要
Abstract
Objective To explore the clinical efficacy of lactulose and Saccharomyces boulardii powder com-bined with diet regulation in the treatment of functional constipation(FC)in children and its influence on intesti-nal flora.Methods A total of 60 children with FC aged≥3 years and with a disease course of≥3 months who visited our hospital from January 2023 to September 2024 were randomly divided into an observation group and a control group,with 30 cases in each group.The observation group was treated with lactulose combined with Saccharomyces boulardii powder,while the control group was treated with lactulose alone.In addition,both groups were given diet regulation,and the treatment lasted for 1 month continuously.The overall clinical efficacy of the two groups,the improvement of constipation symptoms before and after treatment,the changes in the contents of main intestinal flora(Lactobacillus,Bifidobacterium,Enterobacter,Staphylococcus and Sac-charomyces),and the recurrence situation 3 months after treatment were statistically analyzed and compared.Results 1)Clinical efficacy and constipation symptoms:The total effective rate of the observation group(100%,30/30)was higher than that of the control group(86.7%,26/30)(P<0.05).Compared with before treatment,the scores of defecation difficulty,fecal properties,time of each defecation,defecation frequency and abdominal distension occurrence in the two groups of children decreased significantly after treatment(P<0.05).After treatment,the scores of various constipation symptoms in the observation group were significantly lower than those in the control group(P<0.05).2)Changes in intestinal flora:Compared with before treat-ment,the content of Bifidobacterium in the intestinal tract of the two groups of children increased significantly after treatment(P<0.05),and the contents of Lactobacillus,Enterobacter,Staphylococcus and Saccharomy-ces decreased significantly(P<0.05).After treatment,the content of Bifidobacterium in the intestinal tract of the observation group was higher than that in the control group(P<0.05),and the contents of Lactobacillus,Enterobacter,Staphylococcus and Saccharomyces were lower than those in the control group(P<0.05).3)Recurrence situation:The recurrence rate of the observation group(6.7%,2/30)was lower than that of the control group(19.2%,5/26)(P<0.05).Conclusion Lactulose and Saccharomyces boulardii powder combined with diet regulation in the treatment of FC in children can effectively regulate the intestinal flora,improve the clinical efficacy and reduce the recurrence rate.关键词
功能性便秘/儿童/乳果糖/布拉氏酵母菌/饮食调节/疗效/肠道菌群Key words
Functional constipation/Children/Lactulose/Saccharomyces boulardii/Diet regulation/Effi-cacy/Intestinal flora
