中国肛肠病杂志2025，Vol.45Issue(8)：65-67,3.
血清降钙素原对克罗恩病患者疾病活动度的评估价值
Value of Serum Procalcitonin in Assessing Disease Activity of Patients with Crohn's Disease
姬盼盼 1靳淑丹1
作者信息
- 1. 郑州市第三人民医院北部院区消化内科(河南 郑州 450044)
- 折叠
摘要
Abstract
Objective To explore the value of serum procalcitonin(PCT)in assessing the disease activity of patients with Crohn's disease(CD).Methods A cross-sectional study was conducted.A total of 100 patients with CD diagnosed in our department from March 2022 to February 2024 were included.All patients underwent examinations for serum PCT,C-reactive protein(CRP),interleukin-6(IL-6),platelet count(PLT),and erythrocyte sedimentation rate(ESR).Spearman correlation analysis was used to assess the corre-lation between PCT and the above other indexes,and the diagnostic efficacy of each index for moderate to severe active CD was analyzed by receiver operating characteristic(ROC)curve.Results The PCT level in patients with active CD was significantly higher than that in patients with remission CD(P<0.05).The serum level of PCT in patients with moderate to severe active CD was significantly higher than that in patients with mild active CD(P<0.05).Spearman correlation analysis showed that the serum level of PCT in patients with CD was positively correlated with the levels of CRP,IL-6,ESR and PLT(P<0.05).ROC curve analysis showed that the area under the curve(AUC)of PCT for diagnosing moderate to severe active CD was 0.889,and the optimal cut-off value was 0.053 μg/L.The diagnostic efficacy of serum PCT was better than that of CRP(AUC=0.843),IL-6(AUC=0.830),ESR(AUC=0.637)and PLT(AUC=0.741).Conclu-sion Serum PCT can be used as an effective biomarker for assessing the disease activity of CD.关键词
克罗恩病/降钙素原/疾病活动度/评估Key words
Crohn's disease/Procalcitonin/Disease activity/Assessment引用本文复制引用
姬盼盼,靳淑丹..血清降钙素原对克罗恩病患者疾病活动度的评估价值[J].中国肛肠病杂志,2025,45(8):65-67,3.
