中国实用内科杂志2025，Vol.45Issue(7)：564-569,587,7.DOI:10.19538/j.nk2025070105
阵发性睡眠性血红蛋白尿症常见并发症与合并症的处理
Management of common complications and comorbidities in paroxysmal nocturnal hemoglobinuria
摘要
Abstract
This article reviews the management strategies for common complications and comorbidities of paroxysmal nocturnal hemoglobinuria(PNH),with a focus on addressing thrombosis,chronic renal insufficiency,pulmonary hypertension,bone marrow failure,and infections.Key strategies include:using complement inhibitors as the cornerstone to reduce thrombosis and hemolysis risks,combining anticoagulation therapy to prevent thrombotic events,protecting renal function through supportive care,and employing targeted medications to improve pulmonary hypertension.Immunosuppressive therapy or hematopoietic stem cell transplantation is utilized to correct bone marrow failure,while enhanced vaccination and antibiotic prophylaxis are emphasized to prevent infections.The article also covers special issues such as iron metabolism disorders and pregnancy management,highlighting the importance of multidisciplinary collaboration.关键词
阵发性睡眠性血红蛋白尿症/并发症/合并症Key words
paroxysmal nocturnal hemoglobinuria/complications/comorbidities分类
医药卫生引用本文复制引用
贾晋松..阵发性睡眠性血红蛋白尿症常见并发症与合并症的处理[J].中国实用内科杂志,2025,45(7):564-569,587,7.基金项目
北京大学人民医院研究与发展基金(RDL2022-21) （RDL2022-21）
