中国实用内科杂志2025，Vol.45Issue(7)：600-605,6.DOI:10.19538/j.nk2025070110
血液重症监护室中恶性血液病合并危重新型冠状病毒肺炎的疗效分析
Analysis of hematology ICU treatment of patients with hematological malignancies complicated with critical COVID-19
摘要
Abstract
Objective To retrospectively analyze the treatment of patients with hematological malignancies(HM)complicated with critical coronavirus disease 2019(COVID-19)in the hematology intensive care unit(ICU).Methods The study included patients with hematological malignancy and critical COVID-19 admitted to the hematology ICU of the First Affiliated Hospital of Soochow University from December 15,2022,to March 10,2023.Demographic data,clinical manifestations,laboratory and imaging examination indicators,clinical scores and treatment methods were collected by case questionnaire.According to the prognosis,the patients were divided into death group and survival group,and the differences between the two groups were compared.Results A total of 27 patients were enrolled,including 19 patients(70.37％)aged 18-64 years and 8 patients(29.63％)aged ≥65 years.There were 13 males(48.15％)and 14 females(51.85％).Among different hematological malignancies,14 cases(51.85％)were leukemia,8 cases(29.63％)were lymphoma,3 cases(11.11％)were plasma cell diseases,and 2 cases(7.41％)were MDS.Eleven patients(40.74％)were in post-hematopoietic stem cell transplantation status,7 patients(25.93％)received endotracheal intubation mechanical ventilation support,20 patients(74.07％)received non-invasive mechanical ventilation support,4 patients received CRRT support,and 10 patients received vasopressor drug osupport.In this study,the mortality of patients with hematological malignancies and critical COVID-19 was 44.4％(12/27).The comparison between the two groups showed that the white blood cell(WBC)and neutrophil(ANC)count levels in the death group were lower,the time from the onset of COVID-19 to the hematology ICU was shorter,the sequential organ failure assessment(SOFA)score was higher,and the patients received more mechanical ventilation and vasopressor drug support.Conclusion Patients with hematological malignancies are vulnerable population in the epidemic of 2019-ncov infection.Lower WBC and ANC,and vasopressor therapy are associated with higher mortality.Hematology ICU can provide comprehensive life support for these patients.关键词
恶性血液病/新型冠状病毒肺炎/重症监护室Key words
hematologic malignancies/coronavirus disease 2019(COVID-19)/intensive care unit分类
医药卫生引用本文复制引用
李倩,付建红,谢妍,梁佩淇,刘子溢,王栋,高梦,李渭阳,王荧,吴德沛..血液重症监护室中恶性血液病合并危重新型冠状病毒肺炎的疗效分析[J].中国实用内科杂志,2025,45(7):600-605,6.基金项目
苏州大学横向研究课题(H211284) （H211284）
