中国药房2025，Vol.36Issue(16)：2035-2039,5.DOI:10.6039/j.issn.1001-0408.2025.16.14
抑郁症患者的帕罗西汀稳态谷浓度参考范围分析
Analysis of reference range for paroxetine steady-state trough concentrations in patients with depression
摘要
Abstract
OBJECTIVE To investigate the reference range of steady-state trough concentrations in depression patients taking paroxetine.METHODS Therapeutic drug monitoring data of 890 depression inpatients treated with paroxetine in our hospital from January 1,2023 to December 31,2024 were retrospectively collected.Univariate analysis and multiple linear regression analysis were employed to explore the influencing factors of the steady-state trough concentration of paroxetine,as well as the correlation between concentration and efficacy and adverse reactions.The reference range of steady-state trough concentration was obtained by receiver operating characteristic(ROC)curve method.RESULTS Patients with a greater degree of improvement in therapeutic efficacy exhibited higher steady-state trough concentrations of paroxetine(P＜0.000 1).The steady-state trough concentrations of paroxetine and the ratio of paroxetine steady-state trough concentration to dose(C/D ratio)were significantly lower in male patients and those weighing 60-80 kg compared to female patients and those weighing＜60 kg,respectively(P＜0.05 or P＜0.000 1).The steady-state trough concentration,C/D ratio,dosage,and concomitant medication all showed a positive correlation with therapeutic efficacy(P＜0.05 or P＜0.000 1).Both the steady-state trough concentration and C/D ratio were correlated with liver function impairment,and the C/D ratio was also correlated with urinary retention(P＜0.05 or P＜0.000 1).The critical threshold for the effective concentration of paroxetine was 56.31 ng/mL in the overall population,56.42 ng/mL in males,44.91 ng/mL in females,and 198.90 ng/mL in patients experiencing adverse reactions.CONCLUSIONS The reference range for the steady-state trough concentration of paroxetine in the overall population is 56.31-198.90 ng/mL;for male patients,it is 56.42-198.90 ng/mL,and for female patients,it is 44.91-198.90 ng/mL.Dosage of paroxetine should be reduced as appropriate for female patients and patients with low body weight or abnormal liver function.关键词
帕罗西汀/抑郁症/血药浓度监测/稳态谷浓度/受试者操作特征曲线法Key words
paroxetine/depression/therapeutic drug monitoring/steady-state trough concentrations/ROC curve method分类
医药卫生引用本文复制引用
林晗,林丽萍,刘银芳..抑郁症患者的帕罗西汀稳态谷浓度参考范围分析[J].中国药房,2025,36(16):2035-2039,5.基金项目
福建省卫生健康科技计划项目青年科研课题(No.2024QNA097) （No.2024QNA097）
龙岩市科技创新联合资金、省区域医疗专项卫生项目(No.2023LYF17098) （No.2023LYF17098）
