中国真菌学杂志2025，Vol.20Issue(4)：379-385,7.
295例侵袭性肺部真菌感染患者临床表现及预后的高危因素分析
Clinical manifestations and high risk factors of prognosis in 295 patients with invasive pulmonary fungal in-fection
摘要
Abstract
Objective To analyze the clinical manifestations and high risk factors of prognosis of 295 patients with invasive pulmonary fungal infection.Methods From November 2019 to July 2024,295 patients with invasive pulmonary fungal in-fection in Department of Critical Care Medicine,First Hospital of Qinhuangdao City were selected,and their clinical data were collected retrospectively.After treatment,244 patients survived and 51 patients died within 30 days.The clinical mani-festations and chest computerized scanning(CT)of patients with invasive pulmonary fungal infection were analyzed,prog-nostic risk factors were evaluated using logistic regression analysis.Results The clinical manifestations of 295 patients with invasive pulmonary fungal infection were mainly rales and fever in the lungs,accounting for more than 80%.The CT images of the chest were mainly patchy shadows and cavities,accounting for more than 30%.312 strains of pathogenic fungi isola-ted from 295 patients with invasive pulmonary fungal infection were mainly Candida albicans,C.tropicalis and Aspergil-lus,accounting for 49.04%,20.83%and 18.91%respectively.Multivariate logistic analysis showed that the high risk factors of prognosis of patients with invasive pulmonary fungal infection included acute kidney injury,mechanical ventilation,low level of peripheral blood Hb and low level of peripheral blood PLT(OR=1.679,1.353,1.952,1.384,P<0.05).Conclusion The clinical manifestations and chest CT of patients with invasive pulmonary fungal infection had no specific manifestations.The main pathogens were C.albicans,C.tropicalis and Aspergillus.The high-risk factors affecting the prognosis of patients with invasive pulmonary fungal infection mainly include acute kidney injury,mechanical ventilation,low level of peripheral blood Hb and low level of peripheral blood PLT.Therefore,targeted treatment and nursing measures could be adopted to intervene in high-risk patients.关键词
肺部真菌感染/侵袭性/临床表现/预后/高危因素Key words
pulmonary fungal infection/aggressive/clinical manifestations/prognosis/high risk factors分类
医药卫生引用本文复制引用
孟蕾,刘秀娟,石明,张梅香,孙惠芳,左志刚,金亮..295例侵袭性肺部真菌感染患者临床表现及预后的高危因素分析[J].中国真菌学杂志,2025,20(4):379-385,7.基金项目
河北省中医药管理局计划项目(2025123) （2025123）
秦皇岛市科学技术研究与发展计划项目(202302B040) （202302B040）
