中国真菌学杂志2025，Vol.20Issue(4)：393-398,6.
可可毛色二孢菌致角膜炎的临床诊治并文献回顾
Diagnosis,treatment and literature review of keratitis caused by Lasiodiplodia theobromae
杨达有 1严芝光 1石德富 2张春暖 1吴春礼 1黎海妮 1陈耀艳1
作者信息
- 1. 北部湾精准医学重点实验室,广西壮族自治区 防城港 538000
- 2. 广西壮族自治区防城港市第一人民医院眼科,广西壮族自治区 防城港 538000
- 折叠
摘要
Abstract
Objective To study the diagnosis and treatment processes of keratitis caused by Lasiodiplodia theobromae and reviews the literature of the past 10 years.Methods Corneal scraping samples were collected from the affected areas of 2 keratitis patients admitted to our hospital.Two samples were respectively subjected to microscopy examination,fungal cul-ture,molecular biological examination,and the in-vitro antimierobial susceptibility of the isolated pathogen were performed.Results In both patients,the pathogens were identified as Lasiodiplodia theobromae.In-vitro antimierobial susceptibility tests showed that the pathogens were relatively sensitive to voriconazole and amphotericin B,with minimum inhibitory con-centrations(MICs)of 1 μg/mL and 2 μg/mL,respectively.And clinical use was effective.The previously published studies generally suggest that the affected sites of Lasiodiplodia theobromae were mainly the cornea and body surface.For body surface infections,voriconazole was the first-choice treatment,while for corneal infections,combined treatment with ampho-tericin B was required in addition to other therapies.Conclusions Keratitis caused by Lasiodiplodia theobromae is relatively rare in clinical practice,with great difficulties in diagnosis and treatment.Strain identification and in-vitro antimierobial sus-ceptibility tests may provide more precise medication guidance for clinical practice.关键词
真菌性角膜炎/可可毛色二孢菌/临床用药Key words
fungal keratitis/Lasiodiplodia theobromae/clinical medication分类
医药卫生引用本文复制引用
杨达有,严芝光,石德富,张春暖,吴春礼,黎海妮,陈耀艳..可可毛色二孢菌致角膜炎的临床诊治并文献回顾[J].中国真菌学杂志,2025,20(4):393-398,6.
