中南民族大学学报（自然科学版）2025，Vol.44Issue(6)：738-753,16.DOI:10.20056/j.cnki.ZNMDZK.20250602
手性磷酸催化不对称反应的最新进展
Recent advances in asymmetric reactions catalyzed by chiral phosphoric acids
摘要
Abstract
Chiral phosphoric acid has emerged as a large class of highly efficient and stereoselective chiral Brønsted acid catalysts during the last twenty years.The presence of the Brønsted acidic and Lewis basic sites in chiral phosphoric acids can simultaneously activate both nucleophilic and electrophilic substrates.Additionally,the stereoselectivity can be improved by modulating the electronic and spatial effects of the chiral backbone.In recent years,the asymmetric catalysis of chiral phosphoric acid has made remarkable progress.Chiral phosphoric acid can be used alone as organic small molecule catalyst to catalyze various types of reactions;it also can be used with metals(complexes)to realize synergistic asymmetric catalysis.Herein,research progress on the application of chiral phosphoric acid in catalyzing asymmetric Friedel-Crafts reaction,ring-forming reactions,multi-component reactions,hydrogen transfer reactions,allylation reactions,as well as cascade reactions was reviewed from 2020 to the present.关键词
手性磷酸/不对称Friedel-Crafts反应/不对称成环反应/不对称多组分反应/不对称氢转移反应Key words
chiral phosphoric acid/asymmetric Friedel-Crafts reactions/asymmetric ring-forming reactions/asymmetric multicomponent reactions/asymmetric hydrogen transfer reactions分类
化学化工引用本文复制引用
余慧婷,胡晓允..手性磷酸催化不对称反应的最新进展[J].中南民族大学学报（自然科学版）,2025,44(6):738-753,16.基金项目
国家自然科学基金资助项目(21302233) （21302233）
中央高校基本科研业务费专项资金资助项目(CZY22004) （CZY22004）
