中国合理用药探索2025，Vol.22Issue(7)：70-75,6.DOI:10.3969/j.issn.2096-3327.2025.07.008
甲泼尼龙联合阿奇霉素对重症支原体肺炎患儿免疫功能及血清单核细胞趋化蛋白-4、可溶性生长刺激表达基因2蛋白、乳酸脱氢酶水平的影响
Effect of Methylprednisolone Combined with Azithromycin on Immune Function and Serum Levels of Monocyte Chemoattractant Protein-4,Soluble Suppression of Tumorigenicity 2,and Lactate Dehydrogenase in Children with Severe Mycoplasma Pneumonia
摘要
Abstract
Objective:To observe the effects of methylprednisolone combined with azithromycin on immune function and serum levels of monocyte chemoattractant protein-4(MCP-4),soluble suppression of tumorigenicity 2(sST2),and lactate dehydrogenase(LDH)in children with severe mycoplasma pneumonia.Methods:A total of 92 children with severe mycoplasma pneumonia admitted to a hospital from October 2021 to January 2024 were enrolled and randomized into the control group(n=46,azithromycin alone)and the observation group(n=46,methylprednisolone+azithromyc in).Immune function(CD4+,CD8+,CD4+/CD8+),serum levels of inflammatory indicators[MCP-4,sST2,Toll-like receptor 7(TLR7),tumor necrosis factor-α(TNF-α)],cardiac enzyme profiles[LDH,creatine kinase-MB(CK-MB)],and pulmonary function[maximal mid-expiratory flow(MMEF),forced vital capacity percentage of predicted value(FVC%),forced expiratory volume in 1 second percentage of predicted value(FEV1%)]were compared between the two groups.Clinical efficacy and adverse reactions were also evaluated.Results:After treatment,CD4+,CD4+/CD8+,MMEF,FVC%,and FEV1%increased significantly in both groups,with higher levels in the observation group(P<0.05).CD8+,MCP-4,sST2,TLR7,TNF-α,LDH,and CK-MB decreased significantly in both groups,with lower levels in the observation group(P<0.05).The total effective rate was higher in the observation group(91.30%)than in the control group(76.09%,P<0.05).No significant difference in adverse reaction rates was observed(P>0.05).Conclusion:Methylprednisolone combined with azithromycin improves clinical efficacy in children with severe mycoplasma pneumonia,reduces serum MCP-4 and sST2 levels,and ameliorates cardiac enzyme profiles and pulmonary function.关键词
甲泼尼龙/阿奇霉素/重症支原体肺炎/心肌酶谱/肺功能Key words
methylprednisolone/azithromycin/severe mycoplasma pneumonia/cardiac enzyme profile/pulmonary function分类
医药卫生引用本文复制引用
李群,王琪,邵启国,赵静..甲泼尼龙联合阿奇霉素对重症支原体肺炎患儿免疫功能及血清单核细胞趋化蛋白-4、可溶性生长刺激表达基因2蛋白、乳酸脱氢酶水平的影响[J].中国合理用药探索,2025,22(7):70-75,6.基金项目
南阳市2021年市级科技计划项目(KJGG022) （KJGG022）
