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Reassessing the relationship between major depressive disorder and blood lipids: a comprehensive Mendelian randomisation study

Genmin Sun Disong Xia Baiqiang Xue Xuemin Jian Lixia Peng Baokun Wang Chuanhong Wu Chengwen Gao Lin He Yifeng Xu Xiangzhong Zhao Qian Zhang Hui Cao Yanqin Wen Yongyong Shi James B Potash Jianhua Chen Zhiqiang Li

General Psychiatry2025，Vol.38Issue(3)：P.186-198,13.

General Psychiatry2025，Vol.38Issue(3)：P.186-198,13.DOI:10.1136/gpsych-2024-101900

Reassessing the relationship between major depressive disorder and blood lipids: a comprehensive Mendelian randomisation study

Genmin Sun ¹Disong Xia ¹Baiqiang Xue ²Xuemin Jian ¹Lixia Peng ³Baokun Wang ³Chuanhong Wu ⁴Chengwen Gao ⁴Lin He ¹Yifeng Xu ¹Xiangzhong Zhao ⁴Qian Zhang ⁴Hui Cao ⁵Yanqin Wen ¹Yongyong Shi ⁶James B Potash ⁷Jianhua Chen ⁸Zhiqiang Li⁹

作者信息

1. Shanghai Mental Health Center,Bio-X Institutes,Shanghai Clinical Research Center for Mental Health,Shanghai Key Laboratory of Psychotic Disorders,Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders(Ministry of Education),the Collaborative Innovation Center for Brain Science,Shanghai Jiao Tong University,Shanghai,China
2. The Affliated Hospital of Qingdao University&The Biomedical Sciences Institute of Qingdao University(Qingdao Branch of SJTU Bio-X Institutes),School of Basic Medicine,Qingdao University,Qingdao,Shandong,China School of Public Health,Qingdao University,Qingdao,Shandong,China
3. The Affliated Hospital of Qingdao University&The Biomedical Sciences Institute of Qingdao University(Qingdao Branch of SJTU Bio-X Institutes),School of Basic Medicine,Qingdao University,Qingdao,Shandong,China School of Pharmacy,Qingdao University,Qingdao,Shandong,China
4. The Affliated Hospital of Qingdao University&The Biomedical Sciences Institute of Qingdao University(Qingdao Branch of SJTU Bio-X Institutes),School of Basic Medicine,Qingdao University,Qingdao,Shandong,China
5. Department of Psychiatry,Brain Hospital of Hunan Province(The Second People''s Hospital of Hunan Province),The School of Clinical Medicine,Hunan University of Chinese Medicine,Changsha,Hunan,China
6. Shanghai Mental Health Center,Bio-X Institutes,Shanghai Clinical Research Center for Mental Health,Shanghai Key Laboratory of Psychotic Disorders,Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders(Ministry of Education),the Collaborative Innovation Center for Brain Science,Shanghai Jiao Tong University,Shanghai,China The Affliated Hospital of Qingdao University&The Biomedical Sciences Institute of Qingdao University(Qingdao Branch of SJTU Bio-X Institutes),School of Basic Medicine,Qingdao University,Qingdao,Shandong,China Shandong Provincial Key Laboratory of Metabolic Disease&the Metabolic Disease Institute of Qingdao University,Qingdao,Shandong,China Institute of Social Cognitive and Behavioral Sciences,Shanghai Jiao Tong University,Shanghai,China Institute of Neuropsychiatric Science and Systems Biological Medicine,Shanghai Jiao Tong University,Shanghai,China Shanghai Key Laboratory of Sleep Disordered Breathing,Shanghai,China Department of Psychiatry,the First Teaching Hospital of Xinjang Medical University,Urumqi,Xinjiang,China Changning Mental Health Center,Shanghai,China
7. Department of Psychiatry and Behavioral Sciences,The Johns Hopkins University School of Medicine,Baltimore,Maryland,USA
8. Shanghai Mental Health Center,Bio-X Institutes,Shanghai Clinical Research Center for Mental Health,Shanghai Key Laboratory of Psychotic Disorders,Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders(Ministry of Education),the Collaborative Innovation Center for Brain Science,Shanghai Jiao Tong University,Shanghai,China Department of Psychiatry,the First Teaching Hospital of Xinjang Medical University,Urumqi,Xinjiang,China
9. Shanghai Mental Health Center,Bio-X Institutes,Shanghai Clinical Research Center for Mental Health,Shanghai Key Laboratory of Psychotic Disorders,Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders(Ministry of Education),the Collaborative Innovation Center for Brain Science,Shanghai Jiao Tong University,Shanghai,China The Affliated Hospital of Qingdao University&The Biomedical Sciences Institute of Qingdao University(Qingdao Branch of SJTU Bio-X Institutes),School of Basic Medicine,Qingdao University,Qingdao,Shandong,China School of Public Health,Qingdao University,Qingdao,Shandong,China School of Pharmacy,Qingdao University,Qingdao,Shandong,China Shandong Provincial Key Laboratory of Metabolic Disease&the Metabolic Disease Institute of Qingdao University,Qingdao,Shandong,China Shanghai Key Laboratory of Sleep Disordered Breathing,Shanghai,China
折叠

摘要

关键词

Mendelian Randomisation/mendelian randomi/Major Depressive Disorder/major depressive disorder/High Density Lipoprotein Cholesterol/Dyslipidaemia/Low Density Lipoprotein Cholesterol/disentangle genetic causality

分类

医药卫生

引用本文复制引用

Genmin Sun,Disong Xia,Baiqiang Xue,Xuemin Jian,Lixia Peng,Baokun Wang,Chuanhong Wu,Chengwen Gao,Lin He,Yifeng Xu,Xiangzhong Zhao,Qian Zhang,Hui Cao,Yanqin Wen,Yongyong Shi,James B Potash,Jianhua Chen,Zhiqiang Li..Reassessing the relationship between major depressive disorder and blood lipids: a comprehensive Mendelian randomisation study[J].General Psychiatry,2025,38(3):P.186-198,13.

基金项目

supported by the National Natural Science Foundation of China(82071500,82271540,32370724,82401759,81871055,32070679) （82071500,82271540,32370724,82401759,81871055,32070679）

Shanghai Clinical Research Center for Mental Health(19MC1911100) （19MC1911100）

Shanghai Key Laboratory of Psychotic Disorders(13dz2260500) （13dz2260500）

Shanghai Municipal Administrator of Traditional Chinese Medicine(ZY-(2021-2023)-0207-01) （ZY-(2021-2023）

Shanghai Municipal Health Commission Collaborative Innovation Group(2024CXJQ03) （2024CXJQ03）

Shanghai Science and Technology Innovation Action Program(24JS2840400,24ZR1439900,21Y11921100) （24JS2840400,24ZR1439900,21Y11921100）

Shanghai Municipal Science and Technology Major Project,the National Key R&D Program of China(2023YFA0913804,2024YFA0916603,2022FYC2503300) （2023YFA0913804,2024YFA0916603,2022FYC2503300）

the Program of Shanghai Academic/Technology Research Leader(21XD1423300) （21XD1423300）

Shanghai Pujiang Program(21PJD063) （21PJD063）

Shanghai Municipal Science and Technology Major Project(2017SHZDZX01) （2017SHZDZX01）

Shanghai Municipal Commission of Education(2024AIZD016) （2024AIZD016）

the National Key R&D Program of China(2019YFA0905400,2017YFC0908105,2021YFC2702100) （2019YFA0905400,2017YFC0908105,2021YFC2702100）

National Program for Support of Top-Notch Young Professionals,Taishan Scholar Program of Shandong Province(tstp20240526) （tstp20240526）

the Natural Science Foundation of Shandong Province(ZR2019YQ14,YDZX2021009,2021ZDSYS06). （ZR2019YQ14,YDZX2021009,2021ZDSYS06）

General Psychiatry

ISSN：2096-5923

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