北京中医药大学学报2025，Vol.48Issue(8)：1044-1051,8.DOI:10.3969/j.issn.1006-2157.2025.08.002
手部异常特征与冠状动脉粥样硬化性心脏病的相关性研究
Correlation between abnormal hand features and coronary atherosclerotic heart disease
摘要
Abstract
Objective This study aimed to explore the correlation between abnormal hand features and coronary atherosclerotic heart disease(CHD)to provide clinical data support for digitalized traditional Chinese medicine(TCM)hand diagnosis.Methods A palm key point prediction algorithm was used to automatically capture and collect detailed features of the palm and nails through image analysis and data mining using the hand diagnosis information collection technology based on the NVIDIA Jetson platform and Qt framework.A total of 438 cardiac patients who underwent coronary artery computed tomography angiography(CACTA)in the Department of Cardiology,Dongzhimen Hospital,Beijing University of Chinese Medicine,from December 2023 to April 2024 were included and divided into CHD(148 cases)and non-CHD groups(290 cases)based on the CACTA results.The hand features of the two groups were compared,and abnormal hand features associated with CHD were screened using random forest analysis as well as univariate and multivariate logistic regression analyses.Results Based on the results of univariate logistic regression and random forest analyses,a set of hand-related features associated with CHD were identified and subsequently included in the multivariate logistic regression analysis.These features included the morphology of the thenar eminence,the wrinkles of the thenar eminence,nail shape,nail texture,and the length of the blood vessel in the middle finger.Multivariate logistic regression analysis revealed that hypertrophic thenar eminence[odds ratio(OR):3.049,95%confidence interval(CI):1.430-6.503,P=0.004],presence of wrinkles on the thenar eminence(OR:2.206,95%CI:1.119-4.348,P=0.022),presence of gray-black vertical stripes on the nails(OR:1.981,95%CI:1.173-3.347,P=0.011),uneven nail surface(OR:3.130,95%CI:1.822-5.378,P<0.001),and inward-bending nail surface(OR:5.727,95%CI:1.812-18.102,P=0.003)were positively associated with CHD.In contrast,the blood vessel in the middle finger longer than 1/3 of the phalanx was negatively associated with CHD(OR:0.405,95%CI:0.234-0.702,P=0.001).Conclusion Certain hand features are significantly associated with CHD,providing the valuable clinical data to support for the digitalization of TCM hand diagnosis.关键词
冠状动脉粥样硬化性心脏病/手部特征识别/中医手诊仪/智能诊断/随机森林分析Key words
coronary atherosclerotic heart disease/hand features recognition/traditional Chinese medicine hand diagnostic instrument/intelligent diagnosis/random forest analysis分类
医药卫生引用本文复制引用
周晖,李筱,关之玥,王爽秋,李建雨,陈琪,王豪,胡孔法,徐雪..手部异常特征与冠状动脉粥样硬化性心脏病的相关性研究[J].北京中医药大学学报,2025,48(8):1044-1051,8.基金项目
国家重点研发计划项目(No.2022YFC3502300,No.2022YFC3502302) National Key R&D Program of China(Nos.2022YFC3502300 and 2022YFC3502302) （No.2022YFC3502300,No.2022YFC3502302）
