川北医学院学报2025，Vol.40Issue(8)：986-990,5.DOI:10.3969/j.issn.1005-3697.2025.08.006
DTI-ALPS指数评估颅内大血管狭窄-闭塞患者胶质淋巴系统功能的临床研究
Clinical study on the evaluation of glymphatic system function using the DTI-ALPS index in patients with intracranial large vessel stenosis-occlu-sion
摘要
Abstract
Objective:To explore the clinical application value of diffusion tensor image analysis along the perivascular space(DTI-ALPS)to assess the changes in the function of the glymphatic system(GS)in patients with intracranial large vessel stenosis or occlusion(LVSO).Methods:The clinical and imaging data of 45 patients with unilateral type LVSO and 45 healthy controls(HCs)were retrospectively analyzed.The ABCD2 scores were assessed for the 45 patients with LVSO,and diffusion tensor imaging(DTI)pa-rameters were utilized to calculate the DTI-ALPS indices for both groups.Additionally,the DTI-ALPS indices of both cerebral hemi-spheres in all subjects were computed to evaluate glymphatic system function changes in LVSO patients.Results:The DTI-ALPS index of the cerebral hemisphere on the lesion side of the LVSO group was lower than that on the healthy side and the healthy control group(P<0.001),and there was a negative correlation between the DTI-ALPS index of the cerebral hemisphere on the lesion side of the LV-SO group and the ABCD2 score(r=-0.69,P<0.001).Conclusion:The DTI-ALPS index can evaluate the changes in the function of the glial and lymphatic system in LVSO patients,and it is expected to become a new neuroimaging biomarker and evaluation tool for early risk assessment,diagnosis,treatment planning,and prognosis assessment of LVSO.It has important value in improving patients'quality of life,optimizing clinical outcomes,and saving medical resources.关键词
脑胶质淋巴系统/颅内大血管狭窄-闭塞/沿血管周围间隙扩散张量成像分析Key words
Glymphatic system/Intracranial large vessel stenosis or occlusion/Diffusion tensor image analysis along the perivas-cular space分类
医药卫生引用本文复制引用
任逢春,方妤,廖华强..DTI-ALPS指数评估颅内大血管狭窄-闭塞患者胶质淋巴系统功能的临床研究[J].川北医学院学报,2025,40(8):986-990,5.基金项目
四川省科技厅自然科学基金项目(2024NSFSC1824) （2024NSFSC1824）
成都中医药大学"杏林学者"科研项目(CCCX2023008) （CCCX2023008）
