川北医学院学报2025，Vol.40Issue(8)：991-996,6.DOI:10.3969/j.issn.1005-3697.2025.08.007
益生菌调控联合光动力疗法在种植体周围炎中的应用效果及微生物生态重建分析
Application effect and microbial ecological reconstruction analysis of pro-biotic regulation combined with photodynamic therapy in peri implantitis
摘要
Abstract
Objective:To investigate the effect of probiotic regulation combined with photodynamic therapy in peri-implantitis and its influence on microbial ecological reconstruction.Methods:A total of 106 patients with peri-implantitis were divided into Group A(n=36),Group B(n=35),and Group C(n=35)according to different treatment methods.Group C received conventional treat-ment,Group B received photodynamic therapy based on conventional treatment,and Group A received probiotic regulation combined with photodynamic therapy.Periodontal status indicators[probing depth(PD),sulcus bleeding index(SBI),plaque index(PLI)],marginal bone loss(MBL)measurements,peri-implant bacterial load,gingival crevicular fluid bone metabolism indicators[alkaline phosphatase(ALP),osteocalcin(BGP),osteoprotegerin(OPG)],gingival crevicular fluid inflammatory indicators[interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),high-sensitivity C-reactive protein(hs-CRP)],as well as adverse reactions and recurrence rates at 6-month follow-up were compared among the three groups.Results:The levels of periodontal status in-dicators PD,PLI,and SBI in Group A at 4 weeks,3 months,and 6 months after treatment were lower than those in Group B,which were lower than those in Group C(P<0.05).The MBL measurements in Group A at 3 months and 6 months after treatment were lower than those in Group B,which were lower than those in Group C(P<0.05).The loads of Fusobacterium nucleatum,Aggregatibacter actino-mycetemcomitans,Treponema denticola,Porphyromonas gingivalis,Ekenella corrodens,and Prevotella intermedia in Group A at 4 weeks and 6 months after treatment were lower than those in Group B,which were lower than those in Group C(P<0.05).The levels of bone metabolism indicators ALP,BGP,and OPG in Group A at 4 weeks,3 months,and 6 months after treatment were higher than those in Group B,which were higher than those in Group C(P<0.05).The levels of gingival crevicular fluid inflammatory indicators IL-6,IL-1β,TNF-α,and hs-CRP in Group A at 4 weeks,3 months,and 6 months after treatment were lower than those in Group B,which were lower than those in Group C(P<0.05).There were no statistically significant differences in the incidence of adverse reactions during treatment and the recurrence rate at 6-month follow-up among the three groups(P>0.05).Conclusion:Probiotic regulation combined with photodynamic therapy for the treatment of peri-implantitis can exert synergistic antibacterial effects,improve periodontal indicators,reduce pathogen load,alleviate inflammatory response,and regulate bone metabolism balance.关键词
种植体周围炎/微生物/光动力疗法/益生菌/牙周指标/龈沟液Key words
Peri-implantitis/Microorganism/Photodynamic therapy/Probiotics/Periodontal indicators/Gingival crevicular fluid分类
医药卫生引用本文复制引用
热依拉·艾克兰木,热娜古力·阿不都为力,郭涛,陈冲..益生菌调控联合光动力疗法在种植体周围炎中的应用效果及微生物生态重建分析[J].川北医学院学报,2025,40(8):991-996,6.基金项目
新疆维吾尔自治区自然科学基金(2022D01C316) （2022D01C316）
