川北医学院学报2025，Vol.40Issue(8)：1001-1005,5.DOI:10.3969/j.issn.1005-3697.2025.08.009
益生菌辅助治疗对老年心力衰竭患者的疗效及免疫功能的影响
Effects of combined probiotic adjuvant therapy on efficacy and immune function in elderly patients with heart failure
摘要
Abstract
Objective:To investigate the effect of probiotic adjuvant therapy on efficacy and immune function in elderly patients with heart failure(HF).Methods:103 elderly HF patients was selected and divided into a combination group(n=52)and a control group(n=51)according to different treatment methods.The control group received standard HF therapy,whereas the combination group received adjunctive oral probiotic adjuvant on the basis of the control group.Following 3 months of continuous intervention,param-eters including cardiac function,immunological profiles,nutritional status,exercise tolerance,and quality of life were compared between the groups.Results:After treatment,the ratio of early to late diastolic mitral inflow peak velocities(E/A)and left ventricular ejection fraction(LVEF)in both groups were higher than those of before treatment(P<0.05),and the combination group was higher than the control group(P<0.05).The left ventricular end-systolic diameter(LVESD),N-terminal pro-brain natriuretic peptide(NT-proBNP)levels in both groups decreased(P<0.05),and the combination group was lower than the control group(P<0.05).Immunoglobulin G(IgG),IgA,IgM levels,and Mini Nutritional Assessment-Short Form(MNA-SF)scores in both groups were higher than those of be-fore treatment(P<0.05),the combination group was higher than the control group(P<0.05).The 6-minute walk test(6MWT)dis-tance in both groups was greater than that of before treatment(P<0.05),with the combination group showed a longer distance than the control group(P<0.05).The Minnesota Living with Heart Failure Questionnaire(MLHFQ)scores in both groups were lower than be-fore treatment(P<0.05),with the combination group showed lower scores than the control group(P<0.05).Conclusion:Probiotic adjuvant therapy effectively improves cardiac function,immune status,and nutritional parameters in elderly HF patients.Additionally,this combined regimen demonstrates positive clinical significance in enhancing exercise capacity and quality of life in HF patients.关键词
益生菌/标准化抗心力衰竭治疗/心力衰竭/心功能/免疫功能/营养状况Key words
Probiotics/Standardized anti-heart failure therapy/Heart failure/Cardiac function/Immune function/Nutritional status分类
医药卫生引用本文复制引用
刘玉,徐小红,杨诺言,曾子康..益生菌辅助治疗对老年心力衰竭患者的疗效及免疫功能的影响[J].川北医学院学报,2025,40(8):1001-1005,5.基金项目
安徽省自然科学基金项目(2008085QH371) （2008085QH371）
