川北医学院学报2025，Vol.40Issue(8)：1035-1038,4.DOI:10.3969/j.issn.1005-3697.2025.08.017
司美格鲁肽联合二甲双胍治疗肥胖型T2DM的效果及其对胰岛素抵抗和体质量的影响
Effect of semaglutide combined with metformin in the treatment of obese T2DM and its impact on insulin resistance and body mass
摘要
Abstract
Objective:To explore the effect of semaglutide combined with metformin in the treatment of obese type 2 diabetes(T2DM)and its impact on insulin resistance and body mass.Methods:124 obese T2DM patients were included and divided into two groups based on different treatment methods,with 62 cases in each group.The control group was treated with metformin alone,while the study group received additional treatment with semaglutide on top of the control group,both groups were treated for 3 months.The blood glucose indicators[fasting blood glucose(FPG),2-hour postprandial blood glucose(2hPG),glycated hemoglobin(HbA1c)levels],insulin resistance indicators[fasting insulin(FINS),pancreatic beta cell function index(HOMA-β),insulin resistance index(HO-MA-IR)],weight loss effects[waist circumference,body mass,body mass index(BMI)],adiponectin levels,and blood lipid indicators[low-density lipoprotein cholesterol(LDL-C),triglycerides(TG),total cholesterol(TC),and high-density lipoprotein cholesterol(HDL-C)levels]were compared between the two groups.Results:After treatment,the levels of FPG,2hPG,HbA1c,FINS,HOMA-IR,waist circumference,body mass,BMI,and serum levels of TC,TG,and LDL-C in both groups decreased(P<0.05),and the study group were lower than the control group(P<0.05).The HOMA-β,adiponectin,and HDL-C levels increased in both groups(P<0.05),and the study group were higher than the control group(P<0.05).Conclusion:The combination therapy of semaglutide and metformin can more effectively control blood glucose in obese T2DM patients,improve insulin resistance,enhance weight loss,and regulate adiponectin and lipid metabolism levels.关键词
肥胖型2型糖尿病/司美格鲁肽/二甲双胍/血糖/胰岛素抵抗/体质量Key words
Obese type 2 diabetes mellitus/Semaglutide/Metformin/Blood glucose/Insulin resistance/Body mass分类
医药卫生引用本文复制引用
杨矫,孙丽莎,雷星星,袁俊..司美格鲁肽联合二甲双胍治疗肥胖型T2DM的效果及其对胰岛素抵抗和体质量的影响[J].川北医学院学报,2025,40(8):1035-1038,4.基金项目
四川省成都市科技项目(2023-YF09-00052-SN) （2023-YF09-00052-SN）
