摘要
Abstract
In young permanent teeth with pulp necrosis,the current clinical approach for pulp revascularization does not effectively reconstruct functional pulp-like tissue and may lead to root canal calcification.Consequently,regenerative endodontic treatment has garnered widespread attention from scholars.The primary aim of dental pulp tissue regeneration is to restore the activity and functionality of autologous dental pulp tissue,with the rapid formation of a functional vascu-lar network taken as a critical success factor.However,the root canal and medullary cavity present relatively narrow,air-tight,ischemic,and hypoxic environments,which impedes the growth of the functional vascular network from the root ca-nal to the medullary cavity.This challenge has been addressed by researchers who proposed prevascularization technique,which involves the formation of a functional vascular network within engineered tissue to ensure an adequate blood sup-ply to the construct.This vascular network can anastomose with the host vasculature,ultimately facilitating the regenera-tion of vascularized dental pulp tissue.This article reviews potential cell types,growth factors,and scaffold sources perti-nent to scaffold-based prevascularization technology.Three dimension(3D)bioprinting technology related to prevascula-rization is discussed,and a theoretical foundation for advancements in regenerative medicine is provided.关键词
牙髓组织工程/牙髓组织再生/预血管化技术/支架/三维生物打印Key words
pulp tissue engineering/pulp tissue regeneration/prevascularization technique/scaffold/three dimen-sion bioprinting分类
医药卫生
