国际口腔医学杂志2025，Vol.52Issue(5)：644-654,11.DOI:10.7518/gjkq.2025093
原花青素对口腔疾病调控机制和防治的研究进展
Research progress on the regulatory mechanism and prevention and treatment of proanthocyanidins in oral diseases
摘要
Abstract
Proanthocyanidins(PCs),a class of natural compounds with strong antioxidant properties and diverse biolo-gical activities,demonstrate significant potential in the prevention and treatment of oral diseases.They effectively pro-mote the remineralization of dental hard tissues,inhibit the development of dental plaque biofilms,suppress the prolifera-tion of oral cancer cells,and provide beneficial effects in the treatment of oral mucosal diseases.This review highlights that the core advantage of PCs in managing oral diseases stems from their dual-action mechanism:they not only target and inhibit pathogenic biofilms but also modulate the host's oxidative stress and inflammatory responses.Notably,PCs interfere with microbial adhesion and biofilm formation via a non-bactericidal pathway,offering a novel strategy to poten-tially address microbial drug resistance.Although most current research is confined to the laboratory stage,the safety and multipotency of PCs position them as a promising natu-ral adjuvant for oral disease therapy.This review systema-tically summarizes the applications of PCs in prevalent oral diseases and elucidates their biological mecha-nisms,aiming to establish a scientific basis for future clinical translation.关键词
原花青素/口腔疾病/免疫调节/疾病防治Key words
procyanidins/oral diseases/immune regulation/prevention and treatment of diseases分类
医药卫生引用本文复制引用
伍行,刘玉平,张伊钒,夏郁葱,李照禾,易小炜,夏鸿,丁文文..原花青素对口腔疾病调控机制和防治的研究进展[J].国际口腔医学杂志,2025,52(5):644-654,11.基金项目
Science Research Program of the Education Department of Hubei Province(D20224301) （D20224301）
Open Project of Hubei Engineering Research Center for Special Flower Biological Breeding(2023YB003) （2023YB003）
Innovation and Entrepreneur-ship Program for College Students of Hubei Province(S202311336023,S202511336046) 湖北省教育厅科学研究计划(D20224301) （S202311336023,S202511336046）
特色花卉生物育种湖北省工程研究中心开放课题(2023YB003) （2023YB003）
湖北省大学生创新创业项目(S202311336023,S202511336046) （S202311336023,S202511336046）
