国际口腔医学杂志2025，Vol.52Issue(5)：655-661,7.DOI:10.7518/gjkq.2025084
牙源性间充质干细胞来源细胞外囊泡的免疫调节作用
Immune regulation mediated by extracellular vesicles from dental-derived mesenchymal stem cells
摘要
Abstract
Extracellular vesicles(EVs)released by stem cells carry various bioactive molecules that are essential for mediating intercellular communication.Compared with other tissues-derived stem cells,mesenchymal stem cells derived from dental tissues possess several unique advantages,including accessibility,proliferative capacity,and immunomodula-tory potential.EVs secreted by these mesenchymal stem cells have been shown to influence immune cell function and modulate inflammatory responses within local cellular and tissue environments.These immunoregulatory properties are particularly relevant in the context of inflammation-related diseases resulting from trauma,infection,and other pathologi-cal stimuli,highlighting the potential of these EVs in tissue repair and regenerative medicine.This review focuses on the immunomodulatory roles of EVs from mesenchymal stem cells derived from dental tissues and their regulatory functions in oral and systemic inflammatory diseases.关键词
细胞外囊泡/牙源性间充质干细胞/免疫调节Key words
extracellular vesicle/dental-derived mesenchymal stem cell/immune regulation分类
生物科学引用本文复制引用
王博群,陆慧,穆晴,赵玮..牙源性间充质干细胞来源细胞外囊泡的免疫调节作用[J].国际口腔医学杂志,2025,52(5):655-661,7.基金项目
Natural Science Foundation of Guangdong Province(2023A1515012554) （2023A1515012554）
Student Innovation and Entre-preneurship Training Program of Sun Yat-sen University(20240491) 广东省自然科学基金(2023A1515012554) （20240491）
中山大学大学生创新创业计划(20240491) （20240491）
