国际口腔医学杂志2025，Vol.52Issue(5)：662-669,8.DOI:10.7518/gjkq.2025085
正畸诱导性牙根吸收防治策略的研究进展
Advancements in prevention and treatment strategies for orthodontically induced root resorption
摘要
Abstract
Orthodontically induced inflammatory root resorption(OIRR)is one of the most common iatrogenic compli-cations associated with clinical orthodontic treatment,potentially compromising therapeutic outcomes and threatening tooth life.In recent years,various novel strategies have been proposed to mitigate OIRR by enhancing root repair,promo-ting cementum mineralization and minimizing periodontal damage.These emerging approaches aim to modulate cemen-tum metabolism and the microenvironment under mechanical stress through in vitro and in vivo studies.Strategies include the application of physical therapies,hormones,pharmacological agents,nanotechnology-based targeting systems,and stem cell-derived products.Stem cells and their secreted byproducts have shown promise as therapeutic candidates for fa-cilitating cementum regeneration and revealing underlying mechanisms of root resorption repair.This review summarizes recent advancements in the prevention and treatment of OIRR,providing a comprehensive reference for clinical applica-tions and future research directions.关键词
正畸/正畸诱导性牙根吸收/牙骨质/干细胞疗法Key words
orthodontics/orthodontically induced inflammatory root resorption/cementum/stem cell therapy分类
医药卫生引用本文复制引用
刘艺,郑博文,刘奕..正畸诱导性牙根吸收防治策略的研究进展[J].国际口腔医学杂志,2025,52(5):662-669,8.基金项目
Basic Scientific Research Project of Education Department of Liaoning Province(LJKMZ20221190) 辽宁省教育厅高校基本科研项目(LJKMZ20221190) （LJKMZ20221190）
