临床与病理杂志2025，Vol.45Issue(5)：596-604,9.DOI:10.11817/j.issn.2095-6959.2025.250110
双硫死亡与乳腺癌
Disulfidptosis and breast cancer
摘要
Abstract
Disulfidptosis is a newly identified form of regulated cell death characterized by collapse of the actin cytoskeleton due to disulfide stress caused by abnormal accumulation of cystine.Its core mechanism involves the synergistic effect of solute carrier family 7 member 11(SLC7A11)overexpression and glucose metabolic imbalance.Studies have shown that disulfidptosis-related genes exhibit significant heterogeneity in breast cancer,closely associated with breast cancer subtypes,remodeling of the immune microenvironment,and regulation of angiogenesis.Prognostic models constructed based on multi-omics data can effectively predict patient survival,while the identification of key regulatory factors provides new targets for enhancing immunotherapy.At present,targeted drugs such as glucose transporter(GLUT)inhibitors have demonstrated anti-tumor potential in preclinical models,but multiple challenges remain.Future studies should integrate single-cell sequencing with functional validation to explore multi-pathway synergistic mechanisms and to promote the clinical translation of metabolism-immunity combination therapeutic strategies.关键词
双硫死亡/乳腺癌/代谢/氧化还原反应/治疗Key words
disulfidptosis/breast cancer/metabolism/redox reaction/therapy引用本文复制引用
冯意倩,赵昱博,高鸿雁,史含笑,李元栋..双硫死亡与乳腺癌[J].临床与病理杂志,2025,45(5):596-604,9.基金项目
山西省科技厅科技成果转化引导专项(202204021301066).This work was supported by the Shanxi Provincial Science and Technology Department Achievement Transformation Guidance Special Project,China(202204021301066). （202204021301066）
