广州医药2025，Vol.56Issue(7)：918-923,928,7.DOI:10.20223/j.cnki.1000-8535.2025.07.009
血塞通联合右美托咪定对老龄大鼠脑缺血再灌注损伤的保护效果研究
Effects of Xuesaitong combined with dexmedetomidine on cerebral ischemia-reperfusion injury in elderly rats
摘要
Abstract
Objective To explore the effects of Xuesaitong combined with dexmedetomidine on cerebral ischemia-reperfusion in elderly rats.Methods Fifty elderly male Wistar rats were randomly divided into 5 groups:sham operation(C)group,cerebral ischemia-reperfusion(R)group,Xuesaitong(P)group,dexmedetomidine(D)group,Xuesaitong combined with dexmedetomidine(PD)group.Xuesaitong was given in group P,dexmedetomidine was given in group D,and normal saline was given in group C and group R,continuously for 7 days.After 3-and 7-day treatment,the brain of rats was dissected out to assay the area of cerebral infarction,degree of cerebral edema,superoxide dismutase(SOD)and glutathione peroxidase(GSH-PX)activity.Results When compared PD group with P and D group,neurobehavioral score was lower at 3,5,7 day(P＜0.001);area of cerebral infarction,degree of cerebral edema were less(P=0.01,P=0.002),activity of SOD and GSH-PX were higher at 3,7 days(P=0.03,P=0.001)respectively.When compared PD group with D group,area of cerebral infarction,degree of cerebral edema were less(P＜0.01,P=0.008),activity of SOD and GSH-PX were higher at 3,7 days(P=0.009,P＜0.001)respectively.Conclusions The combination of Xuesaitong and dexmedetomidine can obviously reduce the damage by cerebral ischemia-reperfusion in elderly rats and has brain protective effects.关键词
血塞通/右美托咪定/缺血再灌注/脑卒中/大鼠Key words
Xuesaitong/dexmedetomidine/ischemia-reperfusion/stroke/rat引用本文复制引用
李金泽,万晓燕,王秀芹..血塞通联合右美托咪定对老龄大鼠脑缺血再灌注损伤的保护效果研究[J].广州医药,2025,56(7):918-923,928,7.基金项目
山东省中医药科技项目(2021Z009) （2021Z009）
