海南医科大学学报2025，Vol.31Issue(16)：1271-1280,10.DOI:10.13210/j.cnki.jhmu.20250326.005
程序性细胞死亡在阿尔茨海默病中的研究进展
Research on the progress of programmed cell death in Alzheimer's disease
摘要
Abstract
Alzheimer's disease(AD)is a neurodegenerative disorder characterized by progressive impairment of cognitive functions in patients.Currently,its pathogenesis is still unclear and there is a lack of effective clinical treatment.Programmed cell death(PCD)is the genetically determined active and orderly death of cells and is essential for the regulation of homeostasis in life.Increasing evidence suggests that PCD plays an important role in the development of AD.In this paper,we reviewed the molecu-lar mechanisms of six types of PCD,including apoptosis,necroptosis,pyroptosis,ferroptosis,cuproptosis,and disulfidptosis,and their roles in AD,with the aim of providing new perspectives for in-depth study of the pathogenesis and potential therapeutic targets of AD.关键词
阿尔茨海默病/程序性细胞死亡/细胞凋亡/坏死性凋亡/细胞焦亡/铁死亡/铜死亡/双硫死亡Key words
Alzheimer's disease/Programmed cell death/Apoptosis/Necroptosis/Pyroptosis/Ferroptosis/Cuproptosis/Disulfidptosis分类
医药卫生引用本文复制引用
黄颖,康兴宇,高伟,李雪,李思明,李虹霖..程序性细胞死亡在阿尔茨海默病中的研究进展[J].海南医科大学学报,2025,31(16):1271-1280,10.基金项目
This study was supported by the National Natural Science Foundation of China(82105035)and Heilongjiang Provincial Natural Science Foundation of China(LH2023H064) 国家自然科学基金项目(82105035) （82105035）
黑龙江省自然科学基金项目(LH2023H064) （LH2023H064）
