摘要
Abstract
Objective To investigate the association between electrocardiogram(ECG)P-wave parameters and the severity of white matter lesions(WMLs),providing a scientific basis for the prevention and treatment of WMLs.Methods A total of 289 hospitalized patients with WMLs meeting the inclusion criteria were selected as study objects,and all participants underwent routine 12-lead ECG and cranial magnetic resonance imaging examination.These patients were divided into no-mild group(158 cases)and moderate-severe group(131 cases)according to the Fazekas scale scores.We collected clinical data,medical history,ECG P-wave parameters including P-wave duration,P-wave axis and terminal force of P-wave in lead V1(PTFV1),lipid profile,and other data of both groups for comparative analysis.Logistic regression model was used to analyze independent risk factors for WMLs.Results In the moderate-severe group,their age,and the proportions of cases with history of hypertension or diabetes and PTFV1＞4 000 μV·ms were all significantly higher than those in the no-mild group,all with statistically significant differences(all P＜0.01).Multivariate Logistic regression analysis indicated that increased age,hypertension,diabetes,and PTFV1＞4 000 μV·ms were all independent risk factors for WMLs.Conclusion The non-invasive ECG index PTFV1is cost-effective,convenient and easily accessible.It can be used to assess atrial abnormalitie.It contributes to the prevention and treatment of WMLs.关键词
P波参数/脑白质病变/独立危险因素/V1导联P波终末电势/Fazekas量表Key words
P-wave parameter/white matter lesion/independent risk factor/terminal force of P-wave in lead V1/Fazekas scale分类
医药卫生
