内科理论与实践2025，Vol.20Issue(3)：210-215,6.DOI:10.16138/j.1673-6087.2025.03.05
老年射血分数保留型心力衰竭患者合并肌少症预后因素分析
Prognostic factor analysis of sarcopenia in elderly patients with heart failure and preserved ejection fraction
摘要
Abstract
Objective To explore the prognosis and related risk factors of sarcopenia in elderly patients with heart failure and preserved ejection fraction(HFpEF)in some areas of Shanghai.Methods A total of 261 elderly patients(age≥60 years)with HFpEF were consecutively enrolled from January 2018 to June 2020 at Ruijin Hospital,Shanghai Jiao Tong University School of Medicine and collaborating community health service centers/nursing homes.The subjects were grouped according to the presence of sarcopenia,and the relevant clinical data were collected.The follow-up endpoint was subject's readmission for heart failure and(or)all-cause death,and the deadline of follow-up was December 2022.The Kaplan-Meier survival analysis curve and Log-Rank test were performed to compare the outcome between the two groups,and univariate and multivariate Cox proportional hazards regression models were applied to analyze the relevant risk factors of adverse outcome.Results The average time of follow-up was(38.6±11.5)months in the two groups,was(37.4±13.0)months in the sarcopenia group and(39.1±9.3)months in the control group,respectively.The results of Kaplan-Meier survival analysis curve showed that the sarcopenia group had significantly worse prognosis than that in the control group(P<0.05),and multivariate Cox regression analysis showed that sarcopenia was an independent risk factor for poor prognosis in elderly patients with HFpEF(P<0.05).Conclusions This study indicates that sarcopenia was an independent predictor of adverse prognosis in elderly patients with HFpEF.These findings highlight the clinical importance of early identification and management of sarcopenia in these patients,which may help improve clinical outcomes.关键词
射血分数保留型心力衰竭/肌少症/预后/危险因素Key words
Heart failure with preserved ejection fraction/Sarcopenia/Prognosis/Risk factor分类
医药卫生引用本文复制引用
杨启瑞,白婷婷,蒋倩雯,张伟奇,鲁怡音,赵伟,吴方,李菲卡..老年射血分数保留型心力衰竭患者合并肌少症预后因素分析[J].内科理论与实践,2025,20(3):210-215,6.基金项目
中华医学会肠外肠内营养学分会医学营养专项研究项目(Z-2017-24-2403) （Z-2017-24-2403）
