农业生物技术学报2025，Vol.33Issue(9)：1984-1992,9.DOI:10.3969/j.issn.1674-7968.2025.09.010
IGF2R基因多态性与牦牛生长性状的相关性分析
Correlation Analysis Between IGF2R Gene Polymorphisms and Growth Traits in Yak(Bos grunniens)
摘要
Abstract
The insulin-like growth factor 2 receptor(IGF2R)plays a crucial role in physiological processes such as regulating animal growth and development and promoting protein synthesis.To explore the correlation between IGF2R gene polymorphism and growth traits in yak(Bos grunniens).In this study,with 336 individuals from Plateau yak,Huanhu and Xueduo yak in Qinghai province,the SNPs sites were screened by DNA mixed pool sequencing,detected the SNP sites of yak IGF2R gene by direct sequencing,and analyzed the association with growth traits.The results showed that 2 SNPs were screened on the yak IGF2R gene,namely g.96261388T>C(intron 20)and g.96292456A>G(exon 43).The g.96261388T>C locus detected only TT and TC genotypes in 3 yak populations.Three genotypes of AA,AG and GG were detected at g.96292456A>G sites.Analysis of genetic polymorphisms showed that g.96261388T>C and g.96292456A>G met the Hardy-Weinberg equilibrium adaptability test in 3 yak populations(P＞0.05).The results of association analysis showed that chest circumference and tube circumference of Xueduo yak in TC genotype at g.96261388T>C were significantly better than TT genotype;In the g.96292456A>G locus of Plateau yaks,the body length and cannon circumference of individuals with the AA genotype were significantly better than those with the GG genotype(P＜0.05);In Huanhu yaks,the body height,body length,chest circumference and cannon circumference of individuals with the GG genotype were significantly better than those with the AG genotype(P＜0.05).Therefore,the IGF2R genes g.96261388T>C and g.96292456A>G sites were significantly associated with partial yak growth traits,which could be used as molecular markers for yak growth trait breeding.This study provides theoretical basis for yak breeding work.关键词
牦牛/胰岛素样生长因子2受体(IGF2R)/基因多态性/生长性状/SNPKey words
Yak/Insulin-like growth factor 2 receptor(IGF2R)/Gene polymorphism/Growth traits/SNP分类
农业科技引用本文复制引用
吕彩玲,南国雄,王登哲,李永钦,沈秀英,彭巍,徐尚荣,张君..IGF2R基因多态性与牦牛生长性状的相关性分析[J].农业生物技术学报,2025,33(9):1984-1992,9.基金项目
青海省昆仑英才高端创新创业培养团队(2021-NK-A5) （2021-NK-A5）
