护理研究2025，Vol.39Issue(17)：2849-2858,10.DOI:10.12102/j.issn.1009-6493.2025.17.001
微量营养素与2型糖尿病及其并发症关联性的孟德尔随机化研究
Mendelian randomization study on the association between micronutrients and type 2 diabetes mellitus and its complications
摘要
Abstract
Objective:To utilize Mendelian randomization to eliminate confounding factors and reverse causality bias,ascertain the potential causal relationships between micronutrients and type 2 diabetes mellitus,as well as its complications.Methods:Leveraging genome-wide association study(GWAS)data,the exposure factors encompassed 15 micronutrients including minerals such as copper,selenium,zinc,potassium,iron,magnesium,and calcium,as well as vitamins A,B6,folate,B12,C,D,E,and beta-carotene.The outcome variables were type 2 diabetes mellitus and its complications.Mendelian randomization analysis was conducted using methods such as inverse-variance weighted(IVW),MR-Egger,and weighted median,and sensitivity analyses were performed.Results:The results from the inverse-variance weighted(IVW)method and the weighted median method indicated that atherosclerosis was positively correlated with vitamin B12 levels and negatively correlated with vitamin A levels.Chronic renal failure was negatively correlated with folate levels.Type 2 diabetes mellitus was positively correlated with selenium levels,and diabetic macular edema was positively correlated with iron levels.The multivariate Mendelian randomization results revealed that selenium was an independent influencing factor for type 2 diabetes,while vitamin A and vitamin B12 could independently affect the occurrence of atherosclerosis.Conclusions:This study suggests that specific micronutrients may play a regulatory role in type 2 diabetes and its complications.These findings provide support in developing scientific and reasonable dietary guidelines and preventive strategies.关键词
2型糖尿病/并发症/微量营养素/矿物质/微量元素/孟德尔随机化Key words
type 2 diabetes mellitus/complications/micronutrients/minerals/trace elements/Mendelian randomization引用本文复制引用
任颖,杨博文,孙玉梅,李晴晴,刘宝瑜,庞晓丽..微量营养素与2型糖尿病及其并发症关联性的孟德尔随机化研究[J].护理研究,2025,39(17):2849-2858,10.基金项目
国家自然科学基金面上项目,编号:82374394 （）
中医大模型训练数据研究与应用项目,编号:2024120017000260 （）
2024年天津中医药大学研究生科研创新项目,编号:YJSKC-20240034 （）
