现代医药卫生2025，Vol.41Issue(8)：1777-1783,7.DOI:10.3969/j.issn.1009-5519.2025.08.001
妊娠糖尿病孕妇饮食指导影响和miR-149-3p的生物信息学分析
Effect of dietary guidance on pregnant women with gestational diabetes mellitus and bioinformatics analysis of miR-149-3p
摘要
Abstract
Objective To study the effect of dietary adjustment guidance,moderate exercise,scientific weight management and other intervention methods on blood glucose regulation in patients with gestational diabetes mellitus(GDM)through pregnant women's school,and to explore the expression of microRNA-149-3p(miR-149-3p)in GDM patients and its potential clinical significance through bioinformatics analysis.Meth-ods A total of 230 patients with GDM admitted to the hospital from September 2022 to June 2024 were se-lected and divided into study group and control group,with 115 cases in each group.The control group was given simple and necessary guidance from GDM.The study group was given very detailed GDM guidance from the pregnant women's school,including diet guidance,exercise,psychological support,family and social sup-port,follow-up and other aspects of GDM guidance.The patients used their own blood glucose monitor to mo-nitor blood glucose.It was recommended that the pre-meal blood glucose should be controlled at 3.3-5.3 mmol/L,and the postprandial two hours blood glucose should be controlled at 4.4-6.7 mmol/L.Some pa-tients were treated with subcutaneous injection of insulin to reduce blood glucose,and the amount of insulin was adjusted according to the blood glucose.The blood glucose adjustment of the two groups was compared and analyzed.The GSE243374 data set was selected to screen significantly different miRNAs,and miR-149-3p was selected to predict key hub genes.Results The blood glucose control of the patients in the study group was good after intervention,and the differential miRNAs were screened out.Among them,miR-149-3p predic-ted multiple key hub genes.Conclusion GDM patients need to adjust blood glucose from many aspects,close-ly monitor blood glucose,and minimize the occurrence of maternal and fetal pregnancy complications.The key hub genes corresponding to miR-149-3p may be the potential key genes for the pathogenesis of GDM.关键词
血糖/妊娠糖尿病/妊娠并发症/微小RNA-149-3p/生物信息学分析Key words
Blood glucose/Gestational diabetes mellitus/Pregnancy complications/microRNA-149-3p/Bioinformatics analysis分类
医药卫生引用本文复制引用
郭施,李亚军,温芷缘..妊娠糖尿病孕妇饮食指导影响和miR-149-3p的生物信息学分析[J].现代医药卫生,2025,41(8):1777-1783,7.基金项目
广州医科大学附属第二医院临床研究项目(2021-LCYJ-03). （2021-LCYJ-03）
