现代医药卫生2025，Vol.41Issue(8)：1784-1787,1792,5.DOI:10.3969/j.issn.1009-5519.2025.08.002
锐扶刀联合重组人干扰素治疗宫颈高级别鳞状上皮内病变合并人乳头瘤病毒感染的临床疗效研究
Clinical efficacy study of radio-frequency combined with recombinant human interferon in the treatment of high-grade squamous intraepithelial lesions of the cervix combined with human papillomavirus infection
摘要
Abstract
Objective To explore the clinical efficacy of radio-frequency(RF)knife combined with re-combinant human interferon in the treatment of high-grade squamous intraepithelial lesions(HSIL)of the cervix with human papillomavirus(HPV)infection.Methods A total of 60 patients with cervical HSIL com-plicated with HPV infection who were treated in the gynecological clinic of our hospital from July 2023 to June 2024 were randomly divided into observation group and control group using the random number method,with 30 cases in each group.The control group received cervical loop electrosurgical excision procedure(LEEP)combined with recombinant human interferon therapy,while the observation group received radiofrequency(RF)therapy combined with recombinant human interferon therapy.Statistical analysis was conducted on postoperative indicators,HPV clearance rates,and adverse reaction incidence rates in both groups following treatment.Results The rate of vaginal itching,surgery duration,intraoperative blood loss and margin thick-ness were significantly better than those in the control group,with statistically significant differences(P<0.05).However,there were no statistically significant differences between the two groups in terms of the con-cordance rate of cervical tissue pathology before and after surgery,margin positivity rate,HPV seroconversion status,recurrence rate within six months,incidence rate of lower abdomind,and levels of C-reactive protein,tumor necrosis factor-α,and interleukin-10(P>0.05).Conclusion The treatment regimen of RF combined with recombinant human interferon for cervical HSIL combined with HPV infection can significantly reduce surgical time and intraoperative blood loss.At the same time,it can also reduce adverse reactions in patients and improve their prognosis.关键词
锐扶刀/重组人干扰素/宫颈高级别鳞状上皮内病变/人乳头瘤病毒Key words
Radio-frequency knife/Recombinant human interferon/High-grade squamous intraepi-thelial lesions of the cervix/Human papillomavirus分类
医药卫生引用本文复制引用
张胜男,张鸿升,金芬,郭伟堃..锐扶刀联合重组人干扰素治疗宫颈高级别鳞状上皮内病变合并人乳头瘤病毒感染的临床疗效研究[J].现代医药卫生,2025,41(8):1784-1787,1792,5.基金项目
广西壮族自治区卫生健康委员会西医类自筹经费科研课题项目(Z-A20230936). （Z-A20230936）
