现代医药卫生2025，Vol.41Issue(8)：1804-1808,1813,6.DOI:10.3969/j.issn.1009-5519.2025.08.006
注射用尼可地尔联合替格瑞洛对STEMI患者PCI后的预后分析及心功能的影响
Prognostic analysis of nicorandil injection combined with ticagrelor after PCI in patients with STEMI and its effect on cardiac function
摘要
Abstract
Objective To explore the prognostic effects and impact on cardiac function of nicorandil in-jection combined with ticagrelor in patients with acute ST-segment elevation myocardial infarction(STEMI)following percutaneous coronary intervention(PCI).Methods A total of 98 STEMI patients who underwent PCI at our hospital from April 2023 to April 2024 were prospectively selected as study subjects.They were randomly divided into the observation group(50 cases)and the control group(48 cases)using random num-ber method,and baseline characteristics of the two groups were balanced using stratified randomization.The observation group was treated with nicorandil combined with ticagrelor,while the control group received standard antiplatelet therapy.The myocardial microcirculation perfusion indicators(blood flow velocity and myocardial perfusion),myocardial injury markers(creatine kinase-MB and cardiac troponin I),cardiac func-tion indicators(left ventricular ejection fraction and left ventricular diastolic diameter),and short-term prog-nosis(incidence of cardiovascular adverse events)were compared between the two groups.Results After treatment,blood flow velocity,myocardial perfusion,creatine kinase-MB,cardiac troponin I,left ventricular e-jection fraction,and left ventricular diastolic diameter improved significantly in both groups compared to be-fore treatment.The observation group showed more significant improvements in these indicators than the con-trol group,with a significantly lower incidence of cardiovascular adverse events[8.00%(4/50)vs.31.25%(15/48)]compared to the control group.The differences were statistically significant(P<0.05).Conclusion Nic-orandil injection combined with ticagrelor can significantly improve myocardial injury and cardiac function in STEMI patients following PCI and reduce the occurrence of cardiovascular adverse events.关键词
尼可地尔/替格瑞洛/急性ST段抬高型心肌梗死/经皮冠状动脉介入治疗/心功能Key words
Nicorandil/Ticagrelor/Acute ST-segment elevation myocardial infarction/Percuta-neous coronary intervention/Cardiac function分类
医药卫生引用本文复制引用
张小强,郑杰廉..注射用尼可地尔联合替格瑞洛对STEMI患者PCI后的预后分析及心功能的影响[J].现代医药卫生,2025,41(8):1804-1808,1813,6.基金项目
甘肃省定西市科技计划项目(DC2022AR03). （DC2022AR03）
