现代医药卫生2025，Vol.41Issue(8)：1820-1823,4.DOI:10.3969/j.issn.1009-5519.2025.08.009
双环醇片与肝爽颗粒对抗结核药物性肝损伤的疗效分析
Efficacy analysis of bicyclol tablets and GanShuang granules on anti-tuberculosis drug-induced liver injury
摘要
Abstract
Objective To investigate the clinical efficacy of bicyclol tablets and GanShuang granules in the treatment of anti-tuberculosis drug-induced liver injury(ATB-DILI).Methods A total of 150 patients with ATB-DILI admitted to the hospital from January 2022 to August 2024 were selected and divided into group A,group B and group C by random number table method,with 50 cases in each group.They were trea-ted with bicyclol tablets,Ganshuang granules and bicyclol tablets combined with Ganshuang granules,respec-tively.The clinical efficacy of each group was compared.Results The liver function indexes[alanine amin-otransferase(ALT),aspartate aminotransferase(AST)and γ-glutamyl transpeptidase(GGT)]of patients in each group were significantly decreased after treatment.The AST level of patients in group C was significantly lower than that in group A after one month of liver protection treatment,and the levels of ALT,AST and GGT were significantly lower than those in group B.The levels of ALT and AST in group A were significant-ly lower than those in group B.The total effective rate of patients in group C was significantly higher than that in group A and group B,and the reduction of ALT,AST and GGT was significantly higher than that in group A and group B,the differences were statistically significant(P<0.05).Conclusion The combined application of bicyclol tablets and GanShuang granules has a good clinical effect in the treatment of ATB-DILI patients,which provides a reference for clinical medication.关键词
肺结核/护肝药/抗结核药物性肝损伤/抗结核治疗/疗效分析Key words
Pulmonary tuberculosis/Hepatoprotective drugs/Anti-tuberculosis drug-induced liver injury/Anti-tuberculosis treatment/Efficacy analysis分类
医药卫生引用本文复制引用
肖兴,陆秀扬,吴传志,黄勇,侬吟吟,杨静,胡茜,陈美..双环醇片与肝爽颗粒对抗结核药物性肝损伤的疗效分析[J].现代医药卫生,2025,41(8):1820-1823,4.基金项目
贵州省毕节市科学技术联合基金项目(毕科联合[2022]5号). （毕科联合[2022]5号）
