摘要
Abstract
Objective To investigate the clinicopathological features,immunophenotype and prognosis of invasive apocrine carcinoma of the breast.Methods The clinical data,pathological features,immunopheno-type and follow-up data of 13 patients with invasive apocrine carcinoma who met the diagnostic criteria of the World Health Organization in 2019 were analyzed from March 2009 to March 2024 in the Department of Pa-thology,Qufu People's Hospital,Jining City,Shandong Province.Follow-up began when the slice data were collated and analyzed.The shortest follow-up time was eight months,and the longest was 15 years and eight months.Results Of the 13 patients,one was male and 12 were female.The age ranged from 35 to 85 years old,with a median age of 62 years old.In 13 patients,both estrogen and progesterone were negative,and an-drogen receptors were expressed in different proportions,and prolactin-inducible protein 15 was expressed in different degrees.Human epidermal growth factor receptor two(HER2)was positive(3+)in 23.08%(3/13)patients.53.85%(7/13)patients were HER2 negative(0 or 1+).HER2 immunohistochemistry was pos-itive in 23.08%(3/13)of patients,and fluorescence in situ hybridization was negative.Tumor cell prolifera-tion index(Ki-67)positive index greater than or equal to 40%accounted for 23.08%(3/13),<40%-14%accounted for 38.46%(5/13),<14%accounted for 38.46%(5/13).There were two cases(15.38%)of re-currence or metastasis in 13 patients,of which one case died of recurrence or metastasis(7.69%),and the re-maining cases(84.62%)had no recurrence and metastasis,and no disease progression.Conclusion Invasive apocrine carcinoma is mostly triple-negative breast cancer,and most patients can survive long-term disease-free after surgery.Androgen receptor targeted therapy may help to further improve the prognosis of patients with apocrine adenocarcinoma.Whether the prognosis of invasive apocrine carcinoma is better than that of other non-special types of invasive carcinoma still needs to be discussed and studied.关键词
乳腺/浸润性大汗腺癌/病理学Key words
Breast/Invasive apocrine carcinoma/Pathology分类
医药卫生
