应用化学2025，Vol.42Issue(8)：1057-1069,13.DOI:10.19894/j.issn.1000-0518.250259
稀土发光材料在免疫分析中的应用研究进展
Research Progress on the Application of Rare Earth Luminescent Materials in Immunoassay
摘要
Abstract
Rare earth(RE)luminescent materials,leveraging unique optical properties such as long fluorescence lifetimes,large Stokes shifts,and narrow-band emissions,have become pivotal for high-sensitivity immunoassays.Rare earth luminescent materials can be broadly classified into the following categories:1)organic coordination compound-based rare earth luminescent materials,2)inorganic matrix-doped rare earth luminescent materials,and 3)upconversion nanoluminescent materials.This article systematically reviews the properties of rare earth elements,the types and principles of luminescent materials.Based on three biometric detection techniques,namely time-resolved fluorescence detection,near-infrared(NIR-Ⅱ)fluorescence detection,and upconversion fluorescence detection,it delves into the applications of rare earth luminescent materials in the field of immunoassay.Finally,it discusses the challenges these materials face in clinical applications and prospects for future development.关键词
稀土发光材料/时间分辨荧光/免疫分析/生物传感器Key words
Rare earth luminescent materials/Time-resolved fluorescence/Immunoassay/Biosensors分类
化学化工引用本文复制引用
戴斌,彭琳,朱雪宁,王特,杨赛男,张玲玲..稀土发光材料在免疫分析中的应用研究进展[J].应用化学,2025,42(8):1057-1069,13.基金项目
湖南省自然科学基金项目(Nos.2023JJ60207,2024JJ9053,2025JJ80376,2025JJ90206)资助 Supported by Hunan Provincial Natural Science Foundation Project(Nos.2023JJ60207,2024JJ9053,2025JJ80376,2025JJ90206) （Nos.2023JJ60207,2024JJ9053,2025JJ80376,2025JJ90206）
