中国临床药理学杂志2025，Vol.41Issue(14)：1974-1977,4.DOI:10.13699/j.cnki.1001-6821.2025.14.005
纳布啡联合罗哌卡因行程控硬膜外间歇脉冲注射在初产妇分娩镇痛中的临床研究
Clinical trial of ropivacaine combined with nalbuphine for programmed intermittent epidural bolus in labor analgesia of primiparas
摘要
Abstract
Objective To observe the clinical efficacy and safety of 0.1％ropivacaine hydrochloride injection combined with nabufine hydrochloride injection for labor analgesia in primipara(PIEB).Methods Primipara were divided into treatment group and control group.Control group was given 0.1％ropivacaine hydrochloride injection+0.5 μ g·mL-1 sufentanil citrate injection for PIEB;treatment group was given 0.1％ropivacaine hydrochloride injection+0.1 mg·mL-1 nabufine hydrochloride injection for PIEB.The pain digital rating scale(NRS),the total duration of labor,the number of patient-controlled analgesia,the total amount of PIEB,neonatal Apgar score,neonatal umbilical artery blood pH and residual base(BE)were compared between the two groups and the safety was evaluated.Results A total of 92 patients were included,46 cases were included in treatment group and control group,respectively.The NRS scores of treatment group and the control group at 30 minutes of labor analgesia were(3.02±0.58)and(3.51±0.67)points,respectively;at 1 hour of labor analgesia were(2.84±0.39)and(2.31±0 63);at time of uterine orifice was fully opened,were(2.46±1.06)and(3.38±1.25)points,respectively;at the time of delivery were(4.15±0.84)and(4.86±0.93)points,respectively;the times of patient-controlled analgesia were(2.46±0.76)and(4.38±1.45)times,respectively;the total amount of PIEB were(52.75±11.84)and(73.76±15.93)mL,respectively.There were statistically significant differences in the above indicators between the two groups(all P＜0.05).The total labor time of treatment group and control group were(618.92±53.39)and(631.49±65.72)min,respectively,with no statistically significant difference(P＞0.05).The Apgar scores of treatment group and the control group at 1 min after birth were(8.51±0.49)and(8.48±0.54)points,respectively;at 5 minutes after birth were(9.31±0.25)and(9.30±0.32)points,respectively;pH value of umbilical artery blood of newborn were(7.12±0.31)and(7.19±0.52)mmol·L-1,respectively;the BE values were(-3.41±1.45)and(-3.66±1.63)mmol·L-1,respectively.There were no significant difference in the above indexes between the two groups(all P＞0.05).The main adverse drug reactions in treatment group were hypotension,nausea and vomiting and urinary retention,while those in control group were chest distress,nausea and vomiting,urinary retention and pruritus.The adverse drug reaction rates in the treatment group and control group were 13.04％and 10.87％,respectively,with no statistically significant difference in(P＞0.05).关键词
盐酸罗哌卡因注射液/盐酸纳布啡注射液/初产妇/程控硬膜外间歇脉冲注射/分娩镇痛Key words
ropivacaine hydrochloride injection/nalbuphine hydrochloride injection/primipara/programmed intermittent epidural bolus/labor analgesia分类
医药卫生引用本文复制引用
叶小飞,孙海英..纳布啡联合罗哌卡因行程控硬膜外间歇脉冲注射在初产妇分娩镇痛中的临床研究[J].中国临床药理学杂志,2025,41(14):1974-1977,4.基金项目
江西省卫生健康委科技计划基金资助项目(202510878) （202510878）
