中国中西医结合儿科学2025，Vol.17Issue(4)：302-312,11.DOI:10.20274/j.cnki.issn.2025.04.006
基于文献研究的中国孤独症儿童肠道菌群特征分析
Analysis of intestinal microbiome characteristics of children with autism in China based on literature research
摘要
Abstract
Objective To review the characteristics of intestinal microbiome in children with autism spectrum disorder(ASD)based on existing literature evidence,and to explore their correlation with core symptoms of ASD,in order to provide theoretical basis for intestinal microbiome intervention in ASD.Methods The literature on intestinal microbiome characteristics of children with ASD in China was systematically searched for in Wanfang,China national knowledge infrastructure(CNKI),Weipu database(VIP),Web of Science and other relevant databases until January 6,2024.Qualified articles were selected according to inclusion and exclusion criteria,data were extracted,and the quality of the included articles was evaluated using the Newcastle and Ottawa scale(NOS).Results A total of 33 articles were included,and the study subjects were 2 042 children with ASD aged 2 to 14 years.In 16 studies α or β diversity in the intestinal microbiome was analyzed in the children with ASD and healthy children,of which seven reported α and β diversity,five described only α diversity,and four mentioned only β diversity,but the results were inconsistent.At the phylum level,Firmicutes were the most frequently reported,with 9 articles mentioning that their abundance was related to ASD,followed by Bacteroidetes and Proteobacteria,each mentioned in 7 articles.Megamonas,Megasphaera,Barnesiella,Escherichia,Streptococcus and Bifidobacterium were associated with the severity of ASD.Megamonas,Blautia,Streptococcus,Bacteroides,Clostridium,Sutterella,Lactobacillus and Bifidobacterium were reported to be associated with social behavior,while Megamonas was associated with speech disorders.Bifidobacterium,Streptococcus,Blautia and Bacteroides were associated with cognitive development.Clostridium,Lactobacillus and Bifidobacterium were associated with stereotypical behavior,while Bifidobacterium was associated with mood disorders.The abundance of Firmicutes,Bacteroidetes and Bacteroides was associated with gastrointestinal symptoms such as constipation.Conclusion There are significant differences in intestinal microbiome between children with ASD and healthy children.There is a great number of intestinal microbiome involved in the core and accompanying symptoms of ASD,and most of the microbiome associated with ASD belong to phylum Firmicutes,indicating that the abundance of Firmicutes is closely related to the occurrence and development of ASD.关键词
孤独症谱系障碍/肠道菌群/系统综述/中国儿童Key words
Autism spectrum disorder/Intestinal microbiome/Systematic review/Chinese children分类
医药卫生引用本文复制引用
易惺钱,黄敬滢,熊智燚,陈晓凡,刘英,李小艳,王立..基于文献研究的中国孤独症儿童肠道菌群特征分析[J].中国中西医结合儿科学,2025,17(4):302-312,11.基金项目
江西省教育厅科学技术研究项目(GJJ2403625) （GJJ2403625）
江西省中医药管理局科技计划项目(2023A0034) （2023A0034）
江西省双高人才项目(12623009) （12623009）
2022年度江西省(省直单位)名老中医药专家学术经验继承工作项目(赣财社指[2022]81号) Scientific and Technological Research Project of Jiangxi Provincial Department of Education(No.GJJ2403625) （省直单位）
