中国中西医结合儿科学2025，Vol.17Issue(4)：320-323,4.DOI:10.20274/j.cnki.issn.2025.04.008
早产儿促甲状腺素轻度增高与体格及神经心理发育关联性探讨
Exploration of the correlation between mild elevation of thyroid-stimulating hormone and physical and neuropsychological development in preterm infants
摘要
Abstract
To investigate the association between mildly elevated thyroid-stimulating hormone(TSH)levels during the first two weeks of life and physical/neuropsychological development in preterm infants.Methods A total of 102 preterm infants admitted to Sanming First Hospital between March 2021 and March 2023 were enrolled.The cohort comprised 52 infants with mild TSH elevation(observation group)and 50 infants with normal TSH levels(control group).Amplitude-integrated electroencephalography(aEEG)was performed on postnatal day 8.The differences in physical development at corrected age(CA)of 12 months and neuropsychological development at CA of 24 months were evaluated.The neuropsychological development was assessed using the Child Development Behavior Psychological Scale,and developmental quotient≥85 was defined as normal.Results The aEEG monitoring on postnatal day 8 revealed that formation of sleep-wake cycle in the observation group was 26.9%(14/52),lower than that of the control group(46.0%,23/50)(P<0.05).No differences existed in aEEG continuity or voltage parameters(maximum/minimum voltage)between the two groups(P>0.05).At CA of 12 months,the observation group demonstrated significantly smaller body length than the control group[(71.7±2.1)cm vs.(73.9±2.3)cm;P<0.001],while body weight and head circumference showed no significant differences(P>0.05).At CA of 24 months,the development quotient(DQ)of the observation group was lower that that of the control group in fine motor(90.0±2.7 vs.91.6±1.6),language(89.0±2.7 vs.90.0±1.6),and social behavior(91.0±1.7 vs.91.8±1.8)(P<0.05).The DQ in gross motor and adaptive abilities showed no statistical differences between the two groups(P>0.05).Conclusion Mildly elevated TSH levels in preterm infants within 2 weeks after birth are associated with the formation of sleep-wake cycles,physical growth,and neuropsychological development,necessitating monitoring and management.关键词
早产儿/促甲状腺素/神经心理/体格/发育Key words
Preterm infants/Thyroid-stimulating hormone/Neuropsychological/Physical/Development分类
医药卫生引用本文复制引用
魏恩焕,陈玮,陈婉蓉,邓云珍,杨惠..早产儿促甲状腺素轻度增高与体格及神经心理发育关联性探讨[J].中国中西医结合儿科学,2025,17(4):320-323,4.基金项目
三明市科技计划项目(明科[2022]号2022-S-75) Sanming City Science and Technology Program Project(No.2022-S-75) （明科[2022]号2022-S-75）
