中国中医眼科杂志2025，Vol.35Issue(9)：827-833,7.DOI:10.13444/j.cnki.zgzyykzz.2025.09.005
杞精明目汤离子导入治疗结膜松弛症的疗效观察
Efficacy Observation of Ionic Introduction of Qijing Mingmu Decoction in the Treat-ment of Conjunctivochalasis
摘要
Abstract
OBJECTIVE To observe the efficacy of ionic introduction of Qijing Mingmu Decoction in the treatment of conjunctivochalasis(CCh)with liver-kidney Yin deficiency syndrome.METHODS A total of 108 patients(108 eyes)with CCh diagnosed and treated in Shanghai Putuo District Central Hospital from June 2022 to February 2023 were included and randomly divided into the control group(Group A),the 0.9%sodium chloride injection ionic introduction group(Group B),and the Qijing Mingmu Decoction ionic introduction group(Group C),with 36 cases(36 eyes)in each group.Finally,34 cases(34 eyes)were included in Group A,33 cases(33 eyes)in Group B,and 33 cases(33 eyes)in Group C.Group A was treated with 0.1%sodium hyaluronate eye drops,Group B was treated with ionic introduction of 0.9%sodium chloride injection,and Group C was treated with ionic introduction of Qijing Mingmu Decoction.All three groups were treated for eight weeks.The tear film break-up time(BUT),Schirmer I test(SⅠT),Ocular Surface Disease Index(OSDI)scores,and Traditional Chinese Medicine Symptom Scores(TCMSS)of the subjects before and after treatment were detected and statistically analyzed.RESULTS(1)BUT:There were statistically significant differences in the time effect,group effect,and interaction effect between time and group among the three groups(all P＜0.05).When comparing before and after treatment in the three groups,there were no statistically significant differences in the BUT at each time point after treatment compared with that before treatment in Group A(P>0.05).The BUT at each time point after treatment in Groups B and C was longer than that before treatment,and the differences were statistically significant(all P＜0.05).When comparing four weeks after treatment,there was no statistically significant difference in the BUT between Group B and Group A(P>0.05).The BUT in Group C was longer than that in Group A and Group B,and the differences were statistically significant(both P＜0.05).When comparing eight weeks after treatment,the BUT in Group B and Group C was longer than that in Group A,and the differences were statistically significant(both P＜0.05).The BUT in Group C was longer than that in Group B,and the difference was statistically significant(P＜0.05).(2)SⅠT:There were no statistically significant differences in the time effect,group effect,and interaction effect between time and group among the three groups(P＞0.05).There were no statistically significant differences in the SⅠT when comparing before and after treatment in the three groups and at each time point between groups after treatment(P>0.05).(3)OSDI scores:There were statistically significant differences in the time effect,group effect,and interaction effect between time and group(all P＜0.05).When comparing the OSDI before and after treatment in the three groups,there were no statistically significant differences in OSDI scores at each time point after treatment compared with those before treatment in Group A(P>0.05).The OSDI scores at each time point after treatment in Groups B and C were lower than those before treatment,and the differences were statistically significant(all P＜0.05).When comparing four weeks after treatment,the OSDI scores in Group B and Group C were lower than those in Group A,and the differences were statistically significant(both P＜0.05).There were no statistically significant differences in the OSDI scores between Group C and Group B(P>0.05).When comparing eight weeks after treatment,the OSDI scores in Group B and Group C were lower than those in Group A,and the differences were statistically significant(all P＜0.05).The OSDI scores in Group C were lower than those in Group B,and the difference were statistically significant(P＜0.05).(4)TCMSS:There were statistically significant differences in the group effect,time effect,and interaction effect between time and group(all P＜0.05).When comparing the TCMSS before and after treatment in the three groups,there were no statistically significant differences in the TCMSS at each time point after treatment compared with that before treatment in Group A(P>0.05).The TCMSS at each time point after treatment in Groups B and C were lower than those before treatment,and the differences were statistically significant(all P＜0.05).When comparing four weeks after treatment,there were statistically significant differences(P＜0.05).There were no statistically significant differences in the TCMSS between Group A,Group C and Group B(P>0.05).The TCMSS in Group C were lower than those in Group A,and the difference were statistically significant(P＜0.05).When comparing eight weeks after treatment,the TCMSS in Group B and Group C were lower than those in Group A,and the differences were statistically significant(both P＜0.05).The TCMSS in Group C were lower than those in Group B,and the differences were statistically significant(P＜0.05).(5)Clinical efficacy:There was a statistically significant difference in the total effective rate among the three groups(P＜0.05).The total effective rates in Groups B and C were higher than that in Group A,and the differences were statistically significant(both P＜0.05).The total effective rate in Group C was higher than that in Group B,and the difference was statistically significant(P＜0.05).(6)Adverse reactions:There was no statistically significant difference in the incidence of adverse reactions among the three groups(P>0.05).CONCLUSIONS Ionic introduction of Qijing Mingmu Decoction can significantly improve the ocular surface symptoms of patients with CCh of liver-kidney Yin deficiency syndrome and enhance the stability of the tear film.The longer the treatment time,the more obvious the improvement of the clinical outcome.关键词
杞精明目汤/离子导入/结膜松弛症Key words
Qijing Mingmu Decoction/ionic introduction/conjunctivochalasis分类
医药卫生引用本文复制引用
杨倩,杨俊倚,李青松..杞精明目汤离子导入治疗结膜松弛症的疗效观察[J].中国中医眼科杂志,2025,35(9):827-833,7.基金项目
上海市卫生健康委员会临床研究专项(202040148) （202040148）
