组织工程与重建外科杂志2025，Vol.21Issue(4)：383-390,8.DOI:10.3969/j.issn.1673-0364.2025.04.09
双相磷酸钙生物陶瓷材料骨修复的生物机制研究进展
Research advances in the biological mechanism of bone repair with biphasic calcium phosphate bioceramic materials
摘要
Abstract
Biphasic calcium phosphates(BCPs)are bioactive ceramics composed of a mixture of hydroxyapatite and β-tricalcium phosphate in varying proportions,with a chemical composition very similar to the inorganic composition of bone tissue.It has become the most promising bone replacement material due to its excellent biocompatibility,osteoinductivity,osteoconductivity and adjustable degradation rate.This is attributed to the physicochemical properties,pore structure,crystallinity and morphological characteristics of BCP bioceramics.Numerous studies have shown that the bone-forming capacity of BCP bioceramics can be enhanced by optimising their phase composition,ionic environment and surface roughness.However,their potential bone-forming molecular mechanism of action remains a mystery.In this paper,the role of BCP bioceramics in relation to the surrounding biological environment of bone tissues was reviewed,the differentiation of mesenchymal stem cells and immune response-induced bone and vasculogenesis in BCP bioceramics during the process of bone defect repair were introduced,as well as describing modified BCP bioceramics and discussing the future prospects in this field.关键词
双相磷酸钙/改性/生物陶瓷/骨生成Key words
Biphasic calcium phosphates/Modification/Bioactive ceramics/Osteogenesis分类
医药卫生引用本文复制引用
关文阁,唐仁波,华闻达,黄磊云,查杨晓志,孟增东..双相磷酸钙生物陶瓷材料骨修复的生物机制研究进展[J].组织工程与重建外科杂志,2025,21(4):383-390,8.基金项目
云南省卫生健康委员会医学领军人才培养计划(L-218004) （L-218004）
云南省兴滇英才支持计划名医专项(XDYC-MY-2022-0027) （XDYC-MY-2022-0027）
云南省骨科与运动康复临床医学研究中心项目(2023YJZX-GK09) （2023YJZX-GK09）
云南省脊柱脊髓疾病临床医学中心项目(ZX2022000101). （ZX2022000101）
