广西科技大学学报2025，Vol.36Issue(4)：107-113,7.DOI:10.16375/j.cnki.cn45-1395/t.2025.04.013
孔板射流空化对壳聚糖纳米粒5-Fu药物包封效果的影响
The effect of orifice jet cavitation on the drug encapsulation of 5-Fu in chitosan nanoparticles
摘要
Abstract
The aim of this study was to investigate the effect of geometric orifice cavitation on drug encapsulation in chitosan nanoparticles.5-Fluorouracil(5-Fu)was used as a model drug.The effects of pore structure,inlet pressure,oil/water ratio,HLB value and crosslinking time of compound emulsifier on encapsulation efficiency of chitosan nanoparticles were investigated.5-Fu chitosan nanoparticles were characterized.The results show that the pore size of 3.0 mm is more favorable for the preparation of nanoparticles with good encapsulation performance,and the encapsulation efficiency of nanoparticles prepared by porous plates with a smaller open porosity and longer circumference is higher than that by porous plates.Moreover,for orifice plates with the same open area ratio,those with a larger specific perimeter also result in nanoparticles with higher encapsulation rates.As the inlet pressure,oil/water ratio,HLB value and crosslinking time of compound emulsifier increase,the encapsulation efficiency initially increases and then decreases.FTIR analysis shows that after cavitation,5-Fu is successfully loaded into chitosan nanoparticles without any changes in its functional groups,indicating no drug interaction between 5-Fu and chitosan nanoparticles.关键词
孔板空化/壳聚糖纳米粒/包封率/5-氟尿嘧啶(5-Fu)Key words
orifice plate-based cavitation/chitosan nanoparticles/encapsulation efficiency/5-fluorouracil(5-Fu)分类
化学化工引用本文复制引用
郑建滨,张昆明,徐云,黄永春,廖梓成,陆丽金..孔板射流空化对壳聚糖纳米粒5-Fu药物包封效果的影响[J].广西科技大学学报,2025,36(4):107-113,7.基金项目
国家自然科学基金项目(32260601,31701646) （32260601,31701646）
广西科技基地和人才专项(桂科AD19110075) （桂科AD19110075）
广西高等学校高水平创新团队及卓越学者计划项目([2014]7号) （[2014]7号）
广西科技大学博士基金项目(校科博21Z36)资助 （校科博21Z36）
