中国当代医药2025，Vol.32Issue(22)：20-23,4.DOI:10.3969/j.issn.1674-4721.2025.22.04
2型糖尿病患者发生糖尿病酮症酸中毒的影响因素及列线图预测模型的构建
Influencing factors and construction of nomogram prediction model of diabetic ketoacidosis in patients with diabetes mellitus type 2
摘要
Abstract
Objective To explore the risk factors of diabetic ketoacidosis(DKA)in patients with diabetes mellitus type 2(T2DM)and construct a nomogram prediction model.Methods A total of 360 patients with T2DM admitted to the First People's Hospital of Fuzhou City from June 2021 to June 2024 were selected as the research subjects.According to whether the patients developed DKA,they were divided into the occurrence group and the non-occurrence group.The general information of the patients was collected,and the influencing factors of DKA in patients with T2DM were analyzed using the multivariate logistic regression model.Build a model using R software and evaluate the model's performance.Results Among the 360 patients with T2DM,a total of 70 cases developed DKA,accounting for 19.44％.The results of univariate analysis showed that fasting plasma glucose(FPG),glycated hemoglobin,neutrophil-to-lymphocyte ratio(NLR),and platelet-to-lymphocyte ratio(PLR)were associated with the occurrence of DKA in patients with T2DM,and the differences were statistically significant(P＜0.05).The results of multivariate logistic regression showed that FPG(β=1.945,OR=6.994,95％CI:1.704-7.070),glycated hemoglobin(β=2.170,OR=8.758,95％CI:1.168-9.297),NLR(β=2.915,OR=18.442,95％CI:3.783-89.906),PLR(β=3.055,OR=21.221,95％CI:4.515-115.239)were independent risk factors for DKA in patients with T2DM(P＜0.05).Incorporating the above factors into the model,when the C-index was 0.856 and the risk threshold was＞0.03,clinical net benefits can be provided.Conclusion The model constructed based on FPG,glycated hemoglobin,NLR and PLR has good predictive value for the occurrence of DKA in patients with T2DM and can guide the early diagnosis and treatment of the disease.关键词
2型糖尿病/糖尿病酮症酸中毒/危险因素/预测模型Key words
Diabetes mellitus type 2/Diabetic ketoacidosis/Risk factor/Prediction model分类
医药卫生引用本文复制引用
熊亚莉,全美丽,吴丽华..2型糖尿病患者发生糖尿病酮症酸中毒的影响因素及列线图预测模型的构建[J].中国当代医药,2025,32(22):20-23,4.基金项目
江西省卫生健康委科技计划项目(202212868). （202212868）
