中国当代医药2025，Vol.32Issue(23)：57-61,66,6.DOI:10.3969/j.issn.1674-4721.2025.23.12
急性脑梗死患者病情严重程度、脑梗死体积的影响因素分析
Analysis of factors affecting severity of disease and volume of cerebral in-farction in patients with acute cerebral infarction
摘要
Abstract
Objective To investigate the factors affecting severity of disease and volume of cerebral infarction in patients with acute cerebral infarction.Methods The clinical data of 140 patients with acute cerebral infarction admitted to Dong-guan Donghua Hospital and Dongguan Songshan Lake Donghua Hospital from January 2022 to December 2023 were retrospectively analysed.According to the severity of cerebral infarction,they were divided into the light group(82 cases)and the medium-heavy group(58 cases).According to the size of cerebral infarction,they were divided into the small-volume group(60 cases)and the medium-to large-volume group(80 cases).Risk factors affecting the severity and volume of cerebral infarction in patients with acute cerebral infarction were analysed by multifactorial logistic regression.Pearson was used and correlation analyses.Results The results of univariate analysis showed that smoking history,alcohol consumption history,hyperlipidaemia,urine acid(UA),serum albumin(ALB),C-reactive protein(CRP),and C-reactive protein/albumin ratio(CAR)were compared between the light group and medium-heavy group,and the differences were statistically significant(P＜0.05).Smoking history,hyperlipidemia,homocysteine(Hcy),lysophosphatidic acid(LPA),neu-trophil-to-lymphocyte ratio(NLR),monocyte-to-lymphocyte ratio(MLR),and CAR were compared between the small-vol ume group and the medium-to large-volume group,and the differences were statistically significant(P＜0.05).The results of multifactorial logistic regression analysis showed that UA(β=0.063,OR=1.065,95％CI:1.021-1.111)and hyperlipi-daemia(β=2.243,OR=9.423,95％CI:1.180-75.231)were the independent risk factors influencing the severity of the con-dition of patients with acute cerebral infarction,and serum ALB(β=-0.596,OR=0.551,95％CI:0.388-0.781)was a pro-tective factor affecting the severity of disease in patients with acute cerebral infarction(P＜0.05).Hcy(β=2.957,OR=19.248,95％CI:2.508-147.698),LPA(β=1.972,OR=7.187,95％CI:3.593-14.376),NLR(β=1.958,OR=7.088,95％CI:3.217-12.981),MLR(β=1.721,OR=5.592,95％CI:2.792-26.579)were independent risk factors affecting the infarct vol-ume size in patients with acute cerebral infarction(P＜0.05).UA and CAR were all positively correlated with the severity of acute cerebral infarction patients(r=0.795,0.876,P＜0.05),and Hcy,LPA,NLR,MLR,CAR and the size of cerebral in-farction volume were all positively correlated(r=0.885,0.913,0.927,0.894,0.862,P＜0.05).Conclusion UA and hyper-lipidemia are independent risk factors affecting the severity of the disease in patients with acute cerebral infarction,while ALB is a protective factor.Hcy,LPA,NLR and MLR are independent risk factors affecting the size of infarction volume in patients with acute cerebral infarction.The above indicators have a good effect on the condition assessment of patients with acute cerebral infarction.关键词
急性脑梗死/病情严重程度/脑梗死体积/影响因素Key words
Acute cerebral infarction/Severity of disease/Cerebral infarction volume/Influence factor分类
医药卫生引用本文复制引用
龙根,莫金平,刘琳..急性脑梗死患者病情严重程度、脑梗死体积的影响因素分析[J].中国当代医药,2025,32(23):57-61,66,6.基金项目
广东省东莞市社会发展科技项目(20221800902962). （20221800902962）
