中国当代医药2025，Vol.32Issue(24)：4-8,13,6.DOI:10.3969/j.issn.1674-4721.2025.24.01
基于网络药理学探讨利拉鲁肽治疗阿尔茨海默病的作用机制
Exploring the mechanism of Liraglutide treatment for Alzheimer's disease based on network pharmacology
摘要
Abstract
Objective To explore the relevant target genes and main signaling pathways of Liraglutide in the treatment of Alzheimer's disease(AD)based on network pharmacology.Methods The targets of Liraglutide were retrieved through Su-perPred,and the gene targets of Alzheimer's disease were retrieved by using the GeneCards and OMIM databases,fusing the disease targets with the drug action targets.Protein interactions were constructed using the intersection genes of Liraglutide target genes and AD target genes on the String platform.The"Liraglupeptide-component-target"network was constructed using Cytoscape 3.8.2 software,and GO analysis and KEGG enrichment analysis were conducted through databases such as Metascape.The relevant indicators of 8-month-old SAMP8 mice were detected after continuous subcutaneous injection for 2 months.The expressions of β-amyloid protein and mitogen-activated protein kinase in the hippocampus of mice were de-tected by immunofluorescence.Results A total of 131 intersection target genes between Liraglutide and AD were obtained,STAT3,HSP90AA1,CASP3,NFKB1,PTGS2,BCL2L1,MAPK1,ABL1,MCL1 and CASP1 were the core targets.The animal experiments verified that the protein expression of Aβ and MAPK in the model group mice were lower than that in the control group,the protein expression of Aβ and MAPK in the Liraglutide group were higher than that in the model group.Conclusion Based on network pharmacology and animal experiments,the MAPK signaling pathway is a potential target for Liraglutide in the treatment of AD.关键词
利拉鲁肽/阿尔茨海默病/作用机制/网络药理学Key words
Liraglutide/Alzheimer's disease/Mechanism of action/Network pharmacology分类
医药卫生引用本文复制引用
刘忠锦,张海燕,吴迪,王晓宇,郭宇,张可爽,郎尉雅..基于网络药理学探讨利拉鲁肽治疗阿尔茨海默病的作用机制[J].中国当代医药,2025,32(24):4-8,13,6.基金项目
黑龙江省卫生健康委科研项目(20210303070362) （20210303070362）
黑龙江省齐齐哈尔市科技计划联合引导项目(LSFGG-2023039). （LSFGG-2023039）
