临床眼科杂志2025，Vol.33Issue(4)：340-343,4.DOI:10.3969/j.issn.1006-8422.2025.04.010
感染性角膜病病原菌分布及耐药特点分析
Analysis of the distribution and drug-resistant characteristics of infectious keratopathogenic bacteria
马文慧 1张丽丽 1李少玲 1王静1
作者信息
- 1. 266000 青岛,山东第一医科大学附属眼科研究所
- 折叠
摘要
Abstract
Objective To explore the distribution and drug-resistant characteristics of infectious keratopathies,and to provide diagnosis and treatment basis for corneal infectious diseases.Methods Retrospective case study.Analyze the corneal curettage tissue culture specimens from Qingdao Eye Hospital Affiliated to Shandong First Medical University from 2013 to 2023.WHONET 5.6 and SPSS 26 software for the analysis of pathogenic bacteria distribution and resistance characteristics,and the changes in resistance in different years were analyzed using Person's chi-square test and Fisher's exact probability method.Results A total of 13 254 corneal specimens were sent for examination from 2013 to 2023,of which 4 097 cases of positive corneal culture accounted for 30.9%,a total of 1 132 bacterial infected specimens accounted for 8.6%,and 2 965 fungal infected specimens accounted for 22.3%.The main infecting bacteria were Staphylococcus epi-dermidis in 657 cases(58%),Pseudomonas aeruginosa in 135 cases(11.9%)and Staphylococcus aureus in 113 cases(10.0%).The major infecting fungi were Fusarium oxysporum in 1 334 cases(45%),Streptococcus spp.in 771 cases(26%),and Aspergillus spp.in 386 cases(13%).The change of resistance of Staphylococcus epidermidis to benzoxacil-lin and levofloxacin was statistically significant(P<0.05),and the rate of resistance to ocular antimicrobials of Pseudomo-nas aeruginosa in different years was statistically significant(P<0.05);and the rate of resistance of Staphylococcus au-reus to tobramycin and gatifloxacin was statistically significant(P<0.05).Conclusions The rate of fungal detection was higher than that of bacterial detection in infectious keratoconus,and corneal bacterial infection were mainly caused by Staphylococcus epidermidis,and corneal fungal infections were mainly caused by Fusarium.The antimicrobial resistance rates of different bacteria varied with the year.关键词
角膜感染/细菌感染/真菌感染/耐药性Key words
Corneal infection/Bacterial infection/Fungal infection/Drug resistance引用本文复制引用
马文慧,张丽丽,李少玲,王静..感染性角膜病病原菌分布及耐药特点分析[J].临床眼科杂志,2025,33(4):340-343,4.
