环境与职业医学2025，Vol.42Issue(7)：827-832,6.DOI:10.11836/JEOM24505
轮班作业与2型糖尿病关联的病例对照研究
A case-control study on association between shift work and type 2 diabetes mellitus
摘要
Abstract
[Background]With economic development and globalization,shift work has become prevalent across industries.Its relationship with type 2 diabetes mellitus(T2DM)attracts increasing attention. [Objective]To thoroughly explore the relationship between shift work and T2DM,and analyze the impacts of specific shift patterns on T2DM,so as to provide a basis for formulating reasonable shift schedules. [Methods]We conducted a 1∶2 matched case-control study among adults(20-60 years)who or-dered occupational health examinations at the Wuxi No.8 People's Hospital from November to December 2023.The case group comprised 200 T2DM patients,while the controls were 400 age-stratified matched non-diabetic individuals.General demographic characteristics,behavioral habits,medical history,and shift work exposure data(including shift patterns,frequency,and length of service)5 years prior to diagnosis were collected through standardized questionnaires.Logistic regression adjusted for selected confounders was employed to evaluate the association between shift work and T2DM. [Results]The logistic regression analysis demonstrated that shift work was associated with an increased risk of T2DM.After adjusting for confounding factors,shift workers had a 3.55 times higher risk of being diagnosed T2DM compared to non-shift workers(OR=3.55,95％CI:1.026,12.263).The risk varied across different shift patterns,and the three-shift two-rotation system showed the highest risk(OR=4.17,95％CI:1.921,9.035),followed by the two-shift system(OR=2.94,95％CI:2.016,4.281)and four-shift three-rotation system(OR=2.66,95％CI:1.611,6.093).Workers with more than 3 monthly shift days had a 2.74-fold increased risk(95％CI:1.658,4.512)compared to non-shift workers.Additionally,working more than 8 h daily(OR=1.74,95％CI:1.185,2.562)and having more than 20 years of service(OR=2.51,95％CI:1.581,3.976)were both significantly associated with a higher T2DM risk.The trend tests revealed that each incremental increase in monthly shift days and length of service elevated T2DM risk by 2.61 times(95％CI:1.813,3.765)and 1.49 times(95％CI:1.147,1.931),respectively(P＜0.05). [Conclusion]Shift work is an independent risk factor for T2DM,with three-shift two-rotation system posing the highest risk.Shift fre-quency,daily working hours,and length of service are all significant factors affecting the risk of T2DM.These findings support industry-specific shift policy reform and targeted glucose monitoring and health interventions are recommended for workers engaged in high-risk shift patterns(e.g.,three-shift two-rotation system,frequent shifts)and those with prolonged shift work history(＞20 years).关键词
轮班作业/轮班模式/轮班频率/工龄/2型糖尿病/病例对照研究Key words
shift work/shift pattern/shift frequency/length of service/type 2 diabetes mellitus/case-control study分类
医药卫生引用本文复制引用
刘灿,范靖,武卫乐,粱文炯,连玉龙,关素珍..轮班作业与2型糖尿病关联的病例对照研究[J].环境与职业医学,2025,42(7):827-832,6.基金项目
宁夏医科大学校级科研项目(XJ2024003602)、2024年大学生创新创业训练计划校级项目(12) （XJ2024003602）
