南京医科大学学报（自然科学版）2025，Vol.45Issue(9)：1267-1275,9.DOI:10.7655/NYDXBNSN250417
监测免疫治疗反应的颗粒酶B靶向分子影像探针研究进展
Research progress of granzyme B targeted molecular imaging probes for monitoring immunotherapy response
摘要
Abstract
In recent years,cancer immunotherapy,especially immune checkpoint inhibitor(ICI),has made remarkable progress in clinical practice.However,due to the heterogeneity of immune responses among individuals,patients'responses to treatment vary,making the monitoring of treatment efficacy particularly important.In the tumor microenvironment,the activity of cytotoxic T lymphocyte(CTL)is a key indicator for evaluating the efficacy of immunotherapy.Granzyme B(GzmB),a serine protease mainly present in CTLs,is considered as an important biomarker for early prediction of the response to immunotherapy.Molecular imaging probes targeting GzmB can monitor the changes in GzmB expression at tumor sites during immunotherapy,providing a basis for evaluating treatment efficacy.This review summarizes the research progress of various GzmB-targeted molecular probes,and analyzes the structural design,imaging principle of the probes and their application potential in early monitoring of tumor immunotherapy response,aiming to provide reference for the further development and clinical application of GzmB-targeted molecular probes.关键词
癌症/免疫治疗/疗效监测/颗粒酶B/分子影像探针Key words
cancer/immunotherapy/efficacy monitoring/granzyme B/molecular imaging probe分类
医药卫生引用本文复制引用
杨继辰,邱玲,林建国..监测免疫治疗反应的颗粒酶B靶向分子影像探针研究进展[J].南京医科大学学报（自然科学版）,2025,45(9):1267-1275,9.基金项目
国家自然科学基金(22076069) （22076069）
