南京医科大学学报（自然科学版）2025，Vol.45Issue(9)：1334-1341,8.DOI:10.7655/NYDXBNSN250579
重症监护病房急性胰腺炎患者入科首日血清白蛋白与院内死亡风险的相关性研究
A study on the correlation between first-day serum albumin on ICU admission and in-hospital mortality risk in patients with acute pancreatitis
摘要
Abstract
Objective:To investigate the association between first-day serum albumin(ALB)levels upon intensive care unit(ICU)admission and in-hospital mortality in patients with acute pancreatitis(AP),and to explore its potential non-linear nature.Methods:This retrospective study analyzed data from 728 adult AP patients admitted to the ICU for the first time from2008 to 2019,sourced from the MIMIC-IV database.First-day ICU ALB levels and relevant clinical data were extracted.Multivariate logistic regression models were used to assess the linear relationshipbetween ALB and in-hospital mortality.Generalized additive models(GAM)and two-piecewise linear regression models were employed to explore non-linear relationships and identify inflection points.Results:After adjusting for multiple confounders,each 1 g/L increase in first-day ICU ALB was associated with a 27%reduction in in-hospital mortality risk(OR=0.73,95%CI:0.59-0.92,P=0.007).GAM analysis further revealed a significant non-linear relationship between ALB and in-hospital mortality,with an inflection point at 28 g/L.When ALB was≤28 g/L,each 1 g/L increase in ALBwas associated with a 56%significant reduction in mortality risk(OR=0.44,95%CI:0.26-0.73,P=0.001);however,no statistical significance was observed when ALB>28 g/L.Conclusion:First-day ICU serum ALB levels in patients with AP demonstrated a significant non-linear negative association with in-hospital mortality.An ALB level of 28 g/L was identified as an important clinical inflection point for distinguishing high-risk patients.Early monitoring and attention to ALB levels are crucial for risk stratification and clinical decision-making in AP patients.关键词
急性胰腺炎/血清白蛋白/院内病死率/重症监护病房Key words
acute pancreatitis/serum albumin/in-hospital mortality/intensive care unit分类
医药卫生引用本文复制引用
黄东亚,侯超群,葛万里,彭云鹏,蒋奎荣,李强..重症监护病房急性胰腺炎患者入科首日血清白蛋白与院内死亡风险的相关性研究[J].南京医科大学学报（自然科学版）,2025,45(9):1334-1341,8.基金项目
南京医科大学第一附属医院(江苏省人民医院)"临床能力提升工程"面上项目(JSPH-MB-2021-2) （江苏省人民医院）
